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Difference between revisions of "Basics"
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→Basic pathologic differential diagnosis of malignancy
(→Dyscohesive vs. cohesive: chg abbrev) |
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*Benign soft tissue lesions may have marked [[nuclear atypia]] and abundant mitotic activity. | *Benign soft tissue lesions may have marked [[nuclear atypia]] and abundant mitotic activity. | ||
=== | ===General differential diagnosis of malignant lesion=== | ||
This should ''always'' be considered: | This should ''always'' be considered: | ||
<center> | <center> | ||
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A clinically motivated histomorphologic classification of malignancy: | A clinically motivated histomorphologic classification of malignancy: | ||
<center> | <center> | ||
===General histomorphologically motivated differential diagnosis of malignancy=== | |||
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DDX OF MALIGNANCY - THE NEXT STEP | DDX OF MALIGNANCY - THE NEXT STEP | ||
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*''Hematologic'' includes [[lymphoma]], [[leukemia]], [[plasma cell neoplasms]] and others. | *''Hematologic'' includes [[lymphoma]], [[leukemia]], [[plasma cell neoplasms]] and others. | ||
*Memory device ''HMN GEM'': hematologic, melanoma, neuroendocrine carcinoma, germ cell, epithelial, mesenchymal. | *Memory device ''HMN GEM'': hematologic, melanoma, neuroendocrine carcinoma, germ cell, epithelial, mesenchymal. | ||
*The above is a useful clinical classification. The problem is it isn't that useful for problem solving in front of the microscope. | |||
**Germ cell tumours are often not distinctive. | |||
**Numerous epithelioid sarcomas can mimic carcinomas. | |||
**Spindle cell carcinomas can mimic sarcomas very well. | |||
**Neuroendocrine differentiation is not always readily apparent. | |||
===Morphologic grouping=== | ===Morphologic grouping=== | ||