Difference between revisions of "Malignant melanoma"

Jump to navigation Jump to search
43 bytes added ,  17:40, 14 September 2013
Line 343: Line 343:
#S-100 +ve.
#S-100 +ve.
#*Negative staining pretty much excludes the diagnosis.
#*Negative staining pretty much excludes the diagnosis.
#HMB-45 +ve -- especially deep, often patchy
#HMB-45 +ve -- especially deep, often patchy.
#Melan A (MART-1) +ve.
#Melan A (MART-1) +ve.


Line 349: Line 349:
*The standard panel above (S100, HMB-45, MART-1) is also positive in other lesions, e.g. ''[[cellular blue nevus]]''.
*The standard panel above (S100, HMB-45, MART-1) is also positive in other lesions, e.g. ''[[cellular blue nevus]]''.
*Melan A tends to overestimate the number of melanocytes.<ref name=pmid21797920>{{Cite journal  | last1 = Kim | first1 = J. | last2 = Taube | first2 = JM. | last3 = McCalmont | first3 = TH. | last4 = Glusac | first4 = EJ. | title = Quantitative comparison of MiTF, Melan-A, HMB-45 and Mel-5 in solar lentigines and melanoma in situ. | journal = J Cutan Pathol | volume = 38 | issue = 10 | pages = 775-9 | month = Oct | year = 2011 | doi = 10.1111/j.1600-0560.2011.01763.x | PMID = 21797920 }}</ref>
*Melan A tends to overestimate the number of melanocytes.<ref name=pmid21797920>{{Cite journal  | last1 = Kim | first1 = J. | last2 = Taube | first2 = JM. | last3 = McCalmont | first3 = TH. | last4 = Glusac | first4 = EJ. | title = Quantitative comparison of MiTF, Melan-A, HMB-45 and Mel-5 in solar lentigines and melanoma in situ. | journal = J Cutan Pathol | volume = 38 | issue = 10 | pages = 775-9 | month = Oct | year = 2011 | doi = 10.1111/j.1600-0560.2011.01763.x | PMID = 21797920 }}</ref>
**Counting the cell bodies may be better.
*S-100 marks melanocytes and follicular dendritic cells.
*S-100 marks melanocytes and follicular dendritic cells.


48,830

edits

Navigation menu