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Difference between revisions of "Osteosarcoma"
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| Caption = Osteosarcoma. [[H&E stain]]. | | Caption = Osteosarcoma. [[H&E stain]]. | ||
| Micro = cells with malignant features (e.g. nuclear membrane irregularities, marked nuclear size differences, mitoses) surrounded by delicate strands of osteoid | | Micro = cells with malignant features (e.g. nuclear membrane irregularities, marked nuclear size differences, mitoses) surrounded by delicate strands of osteoid | ||
| Subtypes = conventional osteosarcoma (osteoblastic osteosarcoma, [[fibroblastic osteosarcoma]], [[chondroblastic osteosarcoma]]), small cell osteosarcoma, [[telangiectatic osteosarcoma]], [[parosteal osteosarcoma]], periosteal osteosarcoma, [[low-grade central osteosarcoma]], high-grade surface osteosarcoma, | | Subtypes = conventional osteosarcoma (osteoblastic osteosarcoma, [[fibroblastic osteosarcoma]], [[chondroblastic osteosarcoma]]), [[small cell osteosarcoma]], [[telangiectatic osteosarcoma]], [[parosteal osteosarcoma]], periosteal osteosarcoma, [[low-grade central osteosarcoma]], high-grade surface osteosarcoma, [[secondary osteosarcoma]], gnathic osteosarcoma | ||
[[secondary osteosarcoma]], gnathic osteosarcoma | | LMDDx = [[chondrosarcoma]], [[phosphaturic mesenchymal tumour, mixed connective tissue type]], [[undifferentiated pleomorphic sarcoma]] (for fibroblastic osteosarcoma), [[aneurysmal bone cyst]] (for telangiectatic osteosarcoma), [[fibrous dysplasia]], [[small round cell tumours]] (for small cell osteosarcoma) | ||
| LMDDx = [[chondrosarcoma]] | |||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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| Site = [[bone]] | | Site = [[bone]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = [[Li-Fraumeni syndrome]] | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = uncommon | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
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| Prognosis = | | Prognosis = | ||
| Other = | | Other = | ||
| ClinDDx = [[aneurysmal bone cyst]],[[fibrous dysplasia]] | | ClinDDx = [[aneurysmal bone cyst]],[[fibrous dysplasia]], [[Ewing sarcoma]] | ||
}} | }} | ||
'''Osteosarcoma''', also known as '''osteogenic sarcoma''', a malignant [[bone]] tumour. It is grouped with the [[chondro-osseous tumours]]. | '''Osteosarcoma''', also known as '''osteogenic sarcoma''', is a malignant [[bone]] tumour. It is grouped with the [[chondro-osseous tumours]]. | ||
==General== | ==General== | ||
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**Osteoid on H&E: pink, homogenous, "glassy". | **Osteoid on H&E: pink, homogenous, "glassy". | ||
**Tumours typically very cellular - when compared to normal bone. | **Tumours typically very cellular - when compared to normal bone. | ||
*Large (multinucleated) osteoclast-like giant cells | *+/-Large (multinucleated) osteoclast-like giant cells.<ref>{{cite journal |author=Papalas JA, Balmer NN, Wallace C, Sangueeza OP |title=Ossifying dermatofibroma with osteoclast-like giant cells: report of a case and literature review |journal=Am J Dermatopathol |volume=31 |issue=4 |pages=379-83 |year=2009 |month=June |pmid=19461244 |doi=10.1097/DAD.0b013e3181966747 |url=}}</ref> | ||
DDx: | |||
*[[Chondrosarcoma]]. | |||
*[[Phosphaturic mesenchymal tumour, mixed connective tissue type]]. | |||
*Others. | |||
====Images==== | ====Images==== | ||