Difference between revisions of "Colon"

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Colon (view source)

Revision as of 08:33, 31 July 2013

1,627 bytes removed ,  08:33, 31 July 2013
→‎Microscopic colitis: split out LC
(→‎Microscopic colitis: split out LC)
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==Microscopic colitis==
==Microscopic colitis==
{{ Infobox external links
:''Microscopic colitis'' may refer to a microscopic manifestation of an unspecified disease process that can be apparent macroscopically. This section links to a pair of diseases (''lymphocytic colitis'' and ''collagenous colitis'') that are considered to only have microscopic manifestations and characteristic clinical presentation.
| Name          = Lymphocytic colitis
{{Main|Lymphocytic colitis}}
| EHVSC          = 10184
 
| pathprotocols  =
| wikipedia      =
| pathoutlines  =
}}
:''Microscopic colitis'' may refer to a microscopic manifestation of an unspecified disease process that can be apparent macroscopically. This section deals with a pair of diseases (''lymphocytic colitis'' and ''collagenous colitis'') that are considered to only have microscopic manifestations and characteristic clinical presentation.
===General===
===General===
Presentation:
Presentation:
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===Microscopic===
===Microscopic===
====Lymphocytic colitis====
Features:
*Lots of intraepithelial lymphocytes (>=20/100 lymphocytes/surface epithelial cells<ref name=pmid19109861>{{cite journal |author=Tysk C, Bohr J, Nyhlin N, Wickbom A, Eriksson S |title=Diagnosis and management of microscopic colitis |journal=World J. Gastroenterol. |volume=14 |issue=48 |pages=7280-8 |year=2008 |month=December |pmid=19109861 | PMC = 2778111 |doi= |url=http://www.wjgnet.com/1007-9327/14/7280.asp}}</ref>) and
*Lymphocytes in the lamina propria.
Significant negatives:<ref name=hopkins_cc_lc>[http://hopkins-gi.nts.jhu.edu/pages/latin/templates/index.cfm?pg=disease1&disease=29&organ=6&lang_id=1 http://hopkins-gi.nts.jhu.edu/pages/latin/templates/index.cfm?pg=disease1&disease=29&organ=6&lang_id=1]</ref>
*No neutrophils.
*No crypt distortion.
DDx:
*[[Infectious colitis]] - neutrophils present... not lymphocytes.
*[[Collagenous colitis]] - has a band of collagen below the epithelium.
Image:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778111/figure/F2/ LC (nih.gov)].<ref name=pmid19109861/>
====Collagenous colitis====
====Collagenous colitis====
Features:
Features:
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TRANSVERSE COLON, BIOPSY:
TRANSVERSE COLON, BIOPSY:
- COLLAGENOUS COLITIS.
- COLLAGENOUS COLITIS.
</pre>
<pre>
ASCENDING COLON, BIOPSY:
- LYMPHOCYTIC COLITIS.
</pre>
</pre>


====Micro====
====Micro====
=====Lymphocytic colitis=====
The sections show colonic mucosa with abundant intraepithelial lymphocytes (>20 lymphocytes/100 surface epithelial cells). The glandular architecture is within normal limits. No thickened collagen band is apparent below the epithelium.
There are no granulomas. No neutrophilic cryptitis is apparent. The epithelium matures
appropriately to the surface.
=====Collagenous colitis=====
=====Collagenous colitis=====
The sections show colonic mucosa with abundant intraepithelial lymphocytes (>20 lymphocytes/100 surface epithelial cells). A prominent collagen band is apparent below the epithelium (>10 micrometres thick). The glandular architecture is within normal limits.  
The sections show colonic mucosa with abundant intraepithelial lymphocytes (>20 lymphocytes/100 surface epithelial cells). A prominent collagen band is apparent below the epithelium (>10 micrometres thick). The glandular architecture is within normal limits.  
Michael
48,849

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