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Difference between revisions of "Basal cell adenocarcinoma"
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# | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Basal_cell_adenocarcinoma_-_2_-_parotid_gland_-_high_mag.jpg | |||
| Width = | |||
| Caption = Basal cell adenocarcinoma. [[H&E stain]]. | |||
| Micro = unencapsulated lesion with basal-like cells, tubular component - within basal component, dense hyaline stroma around tumour cells | |||
| Subtypes = | |||
| LMDDx = [[adenoid cystic carcinoma]], [[basal cell adenoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[salivary gland]] - usu. parotid gland | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Basal cell adenocarcinoma''', abbreviated ''BCAC'', is an uncommon malignant [[salivary gland]] tumour. | |||
It should ''not'' be confused with ''[[basal cell carcinoma]]'', a very common tumour of the skin. | |||
===General=== | |||
*Very rare. | |||
*Malignant. | |||
*Good prognosis. | |||
*May arise from a ''[[basal cell adenoma]]''.<ref name=pmid8952553/> | |||
===Gross=== | |||
*Usually in the parotid gland ~90% of cases.<ref name=pmid8952553>{{Cite journal | last1 = Muller | first1 = S. | last2 = Barnes | first2 = L. | title = Basal cell adenocarcinoma of the salivary glands. Report of seven cases and review of the literature. | journal = Cancer | volume = 78 | issue = 12 | pages = 2471-7 | month = Dec | year = 1996 | doi = | PMID = 8952553 }}</ref> | |||
===Microscopic=== | |||
Features: | |||
#Lesion is '''not''' encapsulated - '''key feature'''. | |||
#Basal-like cells: | |||
#*Basophilic cells - '''key feature'''. | |||
#*Usually in nests. | |||
#**May be bilayered tubules ''or'' [[trabeculae]]. | |||
#*Large basophilic nucleus. | |||
#*Minimal-to-moderate eosinophilic cytoplasm. | |||
#Stromal cells. | |||
#*Plump spindle cells without significant nuclear atypia. | |||
#**Stromal cell nuclei width ~= diameter [[RBC]]. | |||
#*Dense hyaline stroma. | |||
#Tubular component. | |||
#*Within basal component, may be minimal. | |||
DDx: | |||
*[[Adenoid cystic carcinoma]]. | |||
*[[Basal cell adenoma]] - encapsulated. | |||
*Basaloid [[squamous cell carcinoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Basal_cell_adenocarcinoma_-_parotid_gland_-_intermed_mag.jpg | BCAC - intermed. mag. (WC/Nephron) | |||
Image:Basal_cell_adenocarcinoma_-_parotid_gland_-_high_mag.jpg | BCAC - high mag. (WC/Nephron) | |||
Image:Basal_cell_adenocarcinoma_-_2_-_parotid_gland_-_high_mag.jpg | BCAC - high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.webpathology.com/image.asp?n=5&Case=115 Basal cell adenocarcinoma - intermed. mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?n=6&Case=115 Basal cell adenocarcinoma - high mag. (webpathology.com)]. | |||
==IHC== | |||
Features:<ref name=pmid17922602>{{Cite journal | last1 = Farrell | first1 = T. | last2 = Chang | first2 = YL. | title = Basal cell adenocarcinoma of minor salivary glands. | journal = Arch Pathol Lab Med | volume = 131 | issue = 10 | pages = 1602-4 | month = Oct | year = 2007 | doi = 10.1043/1543-2165(2007)131[1602:BCAOMS]2.0.CO;2 | PMID = 17922602 }}</ref> | |||
*CK7 +ve (strong). | |||
*S100 +ve/-ve. | |||
==See also== | |||
*[[Salivary glands]]. | |||
*[[Head and neck pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Salivary gland]] | |||
[[Category:Head and neck pathology]] | |||