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Keratocystic odontogenic tumour (view source)
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# | '''Keratocystic odontogenic tumour''', abbreviated '''KOT''', is an uncommon [[odontogenic tumour]]. | ||
It was rreviously known as ''odontogenic keratocyst'', abbreviated ''OKC''.<ref name=pmid18353202>{{Cite journal | last1 = Madras | first1 = J. | last2 = Lapointe | first2 = H. | title = Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. | journal = J Can Dent Assoc | volume = 74 | issue = 2 | pages = 165-165h | month = Mar | year = 2008 | doi = | PMID = 18353202 }}</ref> | |||
==General== | |||
*May be associated with ''[[nevoid basal cell carcinoma syndrome]]''. | |||
===Clinical=== | |||
Features:<ref name=pmid17928730>{{Cite journal | last1 = Habibi | first1 = A. | last2 = Saghravanian | first2 = N. | last3 = Habibi | first3 = M. | last4 = Mellati | first4 = E. | last5 = Habibi | first5 = M. | title = Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. | journal = J Oral Sci | volume = 49 | issue = 3 | pages = 229-35 | month = Sep | year = 2007 | doi = | PMID = 17928730 }}</ref> | |||
*Most common presentation: swelling. | |||
==Gross== | |||
*Location: usually mandible. | |||
*May mimic [[ameloblastoma]] radiologically. | |||
==Microscopic== | |||
Features: <ref>Thompson LDR. Head and neck pathology - (Foundations in diagnostic pathology). Goldblum JR, Ed.. Churchill Livingstone. 2006. ISBN 0-443-06960-3.</ref> | |||
*Stratified epithelium (resembling squamous epithelium) with: | |||
**"Ribbon-like appearance" - '''important'''. | |||
***Typically 8-10 cell layers thick - with relatively uniform thickness. | |||
***Lacks rete ridges. | |||
**Palisaded basal cell layer. | |||
*Parakeratosis (keratinized cells with nuclei) - '''key feature'''. | |||
*Artefactual separation of epithelium from the basement membrane. | |||
DDx: | |||
*Odontogenic cyst. | |||
**Orthokeratinized odontogenic cyst<ref name=pmid21062939>{{Cite journal | last1 = Macdonald-Jankowski | first1 = DS. | title = Orthokeratinized odontogenic cyst: a systematic review. | journal = Dentomaxillofac Radiol | volume = 39 | issue = 8 | pages = 455-67 | month = Dec | year = 2010 | doi = 10.1259/dmfr/19728573 | PMID = }}</ref> - usu. [[dentigerous cyst]] - has [[orthokeratosis]] instead of [[parakeratosis]]. | |||
***Orthokeratosis = keratinized cells no nuclei; parakeratosis = keratinized cell with nuclei. | |||
===Images=== | |||
<gallery> | |||
Image:Keratocystic_odontogenic_tumour_-_2_-_intermed_mag.jpg | KOT - intermed. mag. (WC) | |||
Image:Keratocystic_odontogenic_tumour_-_2_-_very_high_mag.jpg | KOT - very high mag. (WC) | |||
Image:Keratocystic_odontogenic_tumour_-_intermed_mag.jpg KOT - another case - intermed. mag. (WC)] | |||
Image:Keratocystic_odontogenic_tumour1.jpg | KOT - poor quality. (WC) | |||
Image:Keratocystic_odontogenic_tumour2.jpg | KOT - showing artefactual clefting - poor quality. (WC) | |||
</gallery> | |||
www: | |||
*[http://ars.els-cdn.com/content/image/1-s2.0-S0968605305000992-gr5.jpg KOT (els-cdn.com)].<ref>URL: [http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5 http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5]. Accessed on: 11 March 2013.</ref> | |||
==See also== | |||
*[[Odontogenic tumours and cysts]]. | |||
*[[Head and neck pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Odontogenic tumours and cysts]] | |||