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Difference between revisions of "Anus"
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→Anal cancer
m (→Micro) |
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*[[Malignant melanoma]]. | *[[Malignant melanoma]]. | ||
*[[Adenocarcinoma]] from the [[rectum]]. | *[[Adenocarcinoma]] from the [[rectum]]. | ||
==Anal squamous cell carcinoma== | |||
*[[AKA]] ''anal squamous carcinoma''. | |||
===General=== | |||
*Most common form of anal cancer. | |||
===Microscopic=== | |||
Features: | |||
*See ''[[squamous cell carcinoma]]''. | |||
===IHC=== | |||
*p16 +ve.<ref name=pmid23105122/> | |||
*CDX2 -ve/+ve. | |||
**May be useful to differentiate from vulva and penis.<ref name=pmid23105122>{{Cite journal | last1 = Gunia | first1 = S. | last2 = Koch | first2 = S. | last3 = May | first3 = M. | title = Is CDX2 immunostaining useful for delineating anorectal from penile/vulvar squamous cancer in the setting of squamous cell carcinoma with clinically unknown primary site presenting with histologically confirmed inguinal lymph node metastasis? | journal = J Clin Pathol | volume = 66 | issue = 2 | pages = 109-12 | month = Feb | year = 2013 | doi = 10.1136/jclinpath-2012-201138 | PMID = 23105122 }}</ref> | |||
==Anal gland adenocarcinoma== | ==Anal gland adenocarcinoma== | ||
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===IHC=== | ===IHC=== | ||
Features:<ref name=pmid22690260/> | Features:<ref name=pmid22690260/> | ||
*CK7 +ve. | *CK7 +ve (5 of 5<ref name=pmid21820151/>). | ||
*p16 -ve (5 of 5<ref name=pmid21820151>{{Cite journal | last1 = Meriden | first1 = Z. | last2 = Montgomery | first2 = EA. | title = Anal duct carcinoma: a report of 5 cases. | journal = Hum Pathol | volume = 43 | issue = 2 | pages = 216-20 | month = Feb | year = 2012 | doi = 10.1016/j.humpath.2011.04.019 | PMID = 21820151 }}</ref>). | |||
*CK20 -ve. | *CK20 -ve. | ||
*CDX2 -ve. | *CDX2 -ve. | ||