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Difference between revisions of "Seminoma"
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It should ''not'' be confused with the unrelated tumour called ''[[spermatocytic seminoma]]''. | It should ''not'' be confused with the unrelated tumour called ''[[spermatocytic seminoma]]''. | ||
==General== | |||
*Male counterpart of the [[dysgerminoma]], which arise in the [[ovary]]. | *Male counterpart of the [[dysgerminoma]], which arise in the [[ovary]]. | ||
*Most common [[germ cell tumour]] of the testis. | *Most common [[germ cell tumour]] of the testis. | ||
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*Rarely, it may present a retroperitoneal mass.<ref name=pmid21424055>{{Cite journal | last1 = Preda | first1 = O. | last2 = Nicolae | first2 = A. | last3 = Loghin | first3 = A. | last4 = Borda | first4 = A. | last5 = Nogales | first5 = FF. | title = Retroperitoneal seminoma as a first manifestation of a partially regressed (burnt-out) testicular germ cell tumor. | journal = Rom J Morphol Embryol | volume = 52 | issue = 1 | pages = 193-6 | month = | year = 2011 | doi = | PMID = 21424055 }}</ref> | *Rarely, it may present a retroperitoneal mass.<ref name=pmid21424055>{{Cite journal | last1 = Preda | first1 = O. | last2 = Nicolae | first2 = A. | last3 = Loghin | first3 = A. | last4 = Borda | first4 = A. | last5 = Nogales | first5 = FF. | title = Retroperitoneal seminoma as a first manifestation of a partially regressed (burnt-out) testicular germ cell tumor. | journal = Rom J Morphol Embryol | volume = 52 | issue = 1 | pages = 193-6 | month = | year = 2011 | doi = | PMID = 21424055 }}</ref> | ||
===Epidemiology & etiology=== | |||
*Arises from ''[[intratubular germ cell neoplasia]]'' (ITGCN). | *Arises from ''[[intratubular germ cell neoplasia]]'' (ITGCN). | ||
==Microsopic== | |||
Features: | Features: | ||
*Cells with fried egg appearance - '''key feature''': | *Cells with fried egg appearance - '''key feature''': | ||
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*Granulomatous orchitis - if [[granuloma]]s are present. | *Granulomatous orchitis - if [[granuloma]]s are present. | ||
===Images=== | |||
<gallery> | <gallery> | ||
Image:Seminoma_high_mag.jpg |Seminoma - high mag. (WC/Nephron) | Image:Seminoma_high_mag.jpg |Seminoma - high mag. (WC/Nephron) | ||
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</gallery> | </gallery> | ||
==IHC== | |||
*D2-40 +ve ~100% of cases.<ref name=pmid17277761>{{Cite journal | last1 = Lau | first1 = SK. | last2 = Weiss | first2 = LM. | last3 = Chu | first3 = PG. | title = D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30. | journal = Mod Pathol | volume = 20 | issue = 3 | pages = 320-5 | month = Mar | year = 2007 | doi = 10.1038/modpathol.3800749 | PMID = 17277761 }}</ref> | *D2-40 +ve ~100% of cases.<ref name=pmid17277761>{{Cite journal | last1 = Lau | first1 = SK. | last2 = Weiss | first2 = LM. | last3 = Chu | first3 = PG. | title = D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30. | journal = Mod Pathol | volume = 20 | issue = 3 | pages = 320-5 | month = Mar | year = 2007 | doi = 10.1038/modpathol.3800749 | PMID = 17277761 }}</ref> | ||
*CD117 +ve (ckit) ~92% of cases.<ref name=pmid17277761/> | *CD117 +ve (ckit) ~92% of cases.<ref name=pmid17277761/> | ||
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*OCT3/4 +ve.<ref name=pmid20438407>{{Cite journal | last1 = Emerson | first1 = RE. | last2 = Ulbright | first2 = TM. | title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. | journal = Pathology | volume = 42 | issue = 4 | pages = 344-55 | month = Jun | year = 2010 | doi = 10.3109/00313021003767355 | PMID = 20438407 }}</ref> | *OCT3/4 +ve.<ref name=pmid20438407>{{Cite journal | last1 = Emerson | first1 = RE. | last2 = Ulbright | first2 = TM. | title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. | journal = Pathology | volume = 42 | issue = 4 | pages = 344-55 | month = Jun | year = 2010 | doi = 10.3109/00313021003767355 | PMID = 20438407 }}</ref> | ||
==Sign out== | |||
<pre> | <pre> | ||
RETROPERITONEAL SOFT TISSUE, RIGHT, CORE BIOPSY: | RETROPERITONEAL SOFT TISSUE, RIGHT, CORE BIOPSY: | ||
- SEMINOMA. | - SEMINOMA. | ||
</pre> | </pre> | ||
===Micro=== | |||
The sections show large atypical, discohesive cells with prominent nucleoli, central | The sections show large atypical, discohesive cells with prominent nucleoli, central | ||
nuclei and moderate clear cytoplasm, intermixed with mature lymphocytes. Mitotic | nuclei and moderate clear cytoplasm, intermixed with mature lymphocytes. Mitotic | ||
activity is present. | activity is present. | ||
===Small biopsy=== | |||
A mixed germ cell tumour cannot be excluded; given the small quantity of tumour, this | A mixed germ cell tumour cannot be excluded; given the small quantity of tumour, this | ||
biopsy is at a high risk for having undersampled other tumour components should they be | biopsy is at a high risk for having undersampled other tumour components should they be | ||
present. Correlation with serology and consideration of re-biopsy is suggested. | present. Correlation with serology and consideration of re-biopsy is suggested. | ||
==See also== | ==See also== | ||