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→‎Spermatocytic seminoma: split-out
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==Spermatocytic seminoma==
==Spermatocytic seminoma==
===General===
{{Main|Spermatocytic seminoma}}
*Rare tumour.
*Only one case of metastases in 200 cases.<ref name=pmid7927308>{{cite journal |author=Eble JN |title=Spermatocytic seminoma |journal=Hum. Pathol. |volume=25 |issue=10 |pages=1035–42 |year=1994 |month=October |pmid=7927308 |doi= |url=}}</ref>
*Orchiectomy is curative.
*Not reported/found in females.<ref name=pmid7927308/>
*Typically older - mean age 50s.<ref name=pmid7927308/>
 
====Epidemiology====
*Does NOT arise from ''[[intratubular germ cell neoplasia]]'' (ITGCN)<ref>{{cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= 10.1111/j.1365-2605.1987.tb00176.x|url=}}</ref> - '''not''' considered a subtype of [[seminoma]].
 
===Microscopic===
Features:<ref>{{cite book |author=Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. |title=Robbins and Cotran pathologic basis of disease |publisher=Elsevier Saunders |location=St. Louis, Mo |year=2005 |pages= |edition=7th |isbn=0-7216-0187-1 |oclc= |doi= |accessdate=}}</ref>
*Population of three cells.
*#Small cells (6-8 µm) - with a large NC [[ratio]].
*#*Look like secondary spermatocytes.
*#*May be confused with (mature) lymphocytes.
*#Medium cells (15-18 µm) with prominent nucleoli.
*#*Filamentous chromatin (AKA ''spireme chromatin'').<ref name=pmid7927308>{{cite journal |author=Eble JN |title=Spermatocytic seminoma |journal=Hum. Pathol. |volume=25 |issue=10 |pages=1035–42 |year=1994 |month=October |pmid=7927308 |doi= |url=}}</ref>
*#Large cells (50-100 µm).
*#*Filamentous chromatin.
*Mucoid lakes.
*Intratubular spread.
 
Notes:
*''Spireme'' = the tangle of filaments in prophase portion of mitosis.<ref>URL: [http://www.thefreedictionary.com/spireme http://www.thefreedictionary.com/spireme]. Accessed on: 4 June 2010.</ref>
*May have eosinophilic cytoplasm (dependent on lab).
**Usually larger than [[Leydig cell tumour]].
 
DDx:
*[[DLBCL]].
*[[Seminoma]].
 
====Images====
<gallery>
Image:Spermatocytic_seminoma_high_mag.jpg | Spermatocytic seminoma - high mag. (WC)
Image:Spermatocytic_seminoma_intermed_mag.jpg | Spermatocytic seminoma - intermed. mag. (WC)
</gallery>
===IHC===
Features:<ref name=pmid10223302>{{Cite journal  | last1 = Kraggerud | first1 = SM. | last2 = Berner | first2 = A. | last3 = Bryne | first3 = M. | last4 = Pettersen | first4 = EO. | last5 = Fossa | first5 = SD. | title = Spermatocytic seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study. | journal = APMIS | volume = 107 | issue = 3 | pages = 297-302 | month = Mar | year = 1999 | doi =  | PMID = 10223302 }}</ref>
*PLAP -ve (0 positive/17).
*CD117 -ve (7 positive/17).
*CAM5.2 -ve (1 positive/17).


==Yolk sac tumour==
==Yolk sac tumour==
Michael
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