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Difference between revisions of "Malignant melanoma"
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→IHC
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==[[IHC]]== | ==[[IHC]]== | ||
===Standard panel=== | ===Standard panel=== | ||
# | #S-100 +ve. | ||
#*Negative staining pretty much excludes the diagnosis. | #*Negative staining pretty much excludes the diagnosis. | ||
#HMB-45 +ve -- | #HMB-45 +ve -- especially deep. | ||
#Melan A (MART-1) +ve. | #Melan A (MART-1) +ve. | ||
Notes: | Notes: | ||
*The standard panel above (S100, HMB-45, MART-1) is also positive in other lesions, e.g. ''[[cellular blue nevus]]''. | *The standard panel above (S100, HMB-45, MART-1) is also positive in other lesions, e.g. ''[[cellular blue nevus]]''. | ||
*Melan A tends to overestimate the number of melanocytes.<ref name=pmid21797920>{{Cite journal | last1 = Kim | first1 = J. | last2 = Taube | first2 = JM. | last3 = McCalmont | first3 = TH. | last4 = Glusac | first4 = EJ. | title = Quantitative comparison of MiTF, Melan-A, HMB-45 and Mel-5 in solar lentigines and melanoma in situ. | journal = J Cutan Pathol | volume = 38 | issue = 10 | pages = 775-9 | month = Oct | year = 2011 | doi = 10.1111/j.1600-0560.2011.01763.x | PMID = 21797920 }}</ref> | |||
*S-100 marks melanocytes and follicular dendritic cells. | |||
===Threshold panel=== | ===Threshold panel=== | ||