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Difference between revisions of "Colon"
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→Collagenous colitis: tweak
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(→Collagenous colitis: tweak) |
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====Collagenous colitis==== | ====Collagenous colitis==== | ||
Features: | Features: | ||
*Intraepithelial lymphocytes | *Intraepithelial lymphocytes - '''important'''. | ||
*Collagenous material in the lamina propria (pink on H&E) -- '''key feature'''. | *Collagenous material in the lamina propria (pink on H&E) -- '''key feature'''. | ||
**Can be demonstrated with a trichrome stain -- collagen = green on trichrome. | **Can be demonstrated with a trichrome stain -- collagen = green on trichrome. | ||
**Subepithelial collagen needs to be >= 10 micrometres thick for diagnosis.<ref name=pmid19109861/> | **Subepithelial collagen needs to be >= 10 micrometres thick for diagnosis.<ref name=pmid19109861/> | ||
***8 micrometres is the diameter of a RBC. | ***8 micrometres is the diameter of a [[RBC]]. | ||
***The normal thickness of the subepithelial collagen is 3 micrometres.<ref name=pmid19109861/> | ***The normal thickness of the subepithelial collagen is 3 micrometres.<ref name=pmid19109861/> | ||
***Transverse colon usually thickest - in one series ~47 micrometres on average.<ref name=pmid10208468>{{Cite journal | last1 = Offner | first1 = FA. | last2 = Jao | first2 = RV. | last3 = Lewin | first3 = KJ. | last4 = Havelec | first4 = L. | last5 = Weinstein | first5 = WM. | title = Collagenous colitis: a study of the distribution of morphological abnormalities and their histological detection. | journal = Hum Pathol | volume = 30 | issue = 4 | pages = 451-7 | month = Apr | year = 1999 | doi = | PMID = 10208468 }}</ref> | ***Transverse colon usually thickest - in one series ~ 47 micrometres on average.<ref name=pmid10208468>{{Cite journal | last1 = Offner | first1 = FA. | last2 = Jao | first2 = RV. | last3 = Lewin | first3 = KJ. | last4 = Havelec | first4 = L. | last5 = Weinstein | first5 = WM. | title = Collagenous colitis: a study of the distribution of morphological abnormalities and their histological detection. | journal = Hum Pathol | volume = 30 | issue = 4 | pages = 451-7 | month = Apr | year = 1999 | doi = | PMID = 10208468 }}</ref> | ||
**Thickening is usually patchy.<ref name=pmid1740280/> | |||
**Thickening "follows the crypts from the surface" - useful for differentiating from tangential sections of the basement membrane.<ref name=bell>Bell, D. 4 Mar 2009.</ref> | **Thickening "follows the crypts from the surface" - useful for differentiating from tangential sections of the basement membrane.<ref name=bell>Bell, D. 4 Mar 2009.</ref> | ||
**Collagen may envelope capillaries - useful to discern from basement membrane.<ref name=bell>Bell, D. 4 Mar 2009.</ref> | **Collagen may envelope capillaries - useful to discern from basement membrane.<ref name=bell>Bell, D. 4 Mar 2009.</ref> | ||