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Difference between revisions of "Intranodal palisaded myofibroblastoma"
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Intranodal palisaded myofibroblastoma (view source)
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Intranodal palisaded myofibroblastoma - very high mag.jpg | | Image = Intranodal palisaded myofibroblastoma - very high mag.jpg | ||
| Width = 200 | |||
| Caption = IPM. [[H&E stain]]. | | Caption = IPM. [[H&E stain]]. | ||
| Micro = | | Micro = spindle cells with nuclear palisading, RBC extravasation | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[ | | LMDDx = [[schwannoma]], [[leiomyoma]] | ||
| Stains = | | Stains = | ||
| IHC = SMA +ve, S-100 -ve. | | IHC = SMA +ve, S-100 -ve. | ||
| Line 35: | Line 14: | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = [[ | | Site = [[lymph node]]. | ||
| Signs = | | Assdx = | ||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = mass lesion | |||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = very rare. | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Line 44: | Line 26: | ||
| Prognosis = | | Prognosis = | ||
| Other = | | Other = | ||
| ClinDDx = [[ | | ClinDDx = [[lymphoma]], metastatic carcinoma. | ||
}} | }} | ||
'''Intranodal palisaded myofibroblastoma''', abbreviated '''IPM''', is a rare tumour that classically presents as an inguinal mass.<ref name=pmid17284119>{{Cite journal | last1 = Nguyen | first1 = T. | last2 = Eltorky | first2 = MA. | title = Intranodal palisaded myofibroblastoma. | journal = Arch Pathol Lab Med | volume = 131 | issue = 2 | pages = 306-10 | month = Feb | year = 2007 | doi = 10.1043/1543-2165(2007)131[306:IPM]2.0.CO;2 | PMID = 17284119 }}</ref> | '''Intranodal palisaded myofibroblastoma''', abbreviated '''IPM''', is a rare tumour that classically presents as an inguinal mass.<ref name=pmid17284119>{{Cite journal | last1 = Nguyen | first1 = T. | last2 = Eltorky | first2 = MA. | title = Intranodal palisaded myofibroblastoma. | journal = Arch Pathol Lab Med | volume = 131 | issue = 2 | pages = 306-10 | month = Feb | year = 2007 | doi = 10.1043/1543-2165(2007)131[306:IPM]2.0.CO;2 | PMID = 17284119 }}</ref> | ||
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#Intracellular and extracellular fuchsinophilic bodies. | #Intracellular and extracellular fuchsinophilic bodies. | ||
#*Smooth muscle actin +ve. | #*Smooth muscle actin +ve. | ||
Notes: | Notes: | ||
*''Fuchsinophilic'' = affinity for the acid dye fuchsin.<ref>URL: [http://www.merriam-webster.com/medical/fuchsinophilic http://www.merriam-webster.com/medical/fuchsinophilic]. Accessed on: 3 October 2011.</ref> | *''Fuchsinophilic'' = affinity for the acid dye fuchsin.<ref>URL: [http://www.merriam-webster.com/medical/fuchsinophilic http://www.merriam-webster.com/medical/fuchsinophilic]. Accessed on: 3 October 2011.</ref> | ||
**Image: [http://www.flickr.com/photos/53376324@N08/5387821397/in/photostream Fuchsinophilic material (flickr.com)] - red. | **Image: [http://www.flickr.com/photos/53376324@N08/5387821397/in/photostream Fuchsinophilic material (flickr.com)] - red. | ||
DDx:<ref>{{Cite journal | last1 = Sarma | first1 = NH. | last2 = Arora | first2 = KS. | last3 = Varalaxmi | first3 = KP. | title = Intranodal palisaded myofibroblastoma: a case report and an update on etiopathogenesis and differential diagnosis. | journal = J Cancer Res Ther | volume = 9 | issue = 2 | pages = 295-8 | month = | year = | doi = 10.4103/0973-1482.113395 | PMID = 23771380 }}</ref> | |||
*[[Schwannoma]]. | |||
*[[Leiomyoma]]. | |||
*[[Leiomyosarcoma]]. | |||
*[[Malignant melanoma]]. | |||
*[[Kaposi sarcoma]]. | |||
*Metastatic carcinoma. | |||
===Images=== | ===Images=== | ||
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Image: Intranodal palisaded myofibroblastoma - high mag.jpg | IPM - high mag. (WC/Nephron) | Image: Intranodal palisaded myofibroblastoma - high mag.jpg | IPM - high mag. (WC/Nephron) | ||
Image: Intranodal palisaded myofibroblastoma - very high mag.jpg | IPM - very high mag. (WC/Nephron) | Image: Intranodal palisaded myofibroblastoma - very high mag.jpg | IPM - very high mag. (WC/Nephron) | ||
Image: Intra-nodal palisaded myofibroblastoma.jpg | IPM - high mag. (WC) | |||
</gallery> | </gallery> | ||
www: | www: | ||
| Line 98: | Line 83: | ||
==IHC== | ==IHC== | ||
*SMA +ve. | *SMA +ve. | ||
*Cyclin D1 +ve. | *Vimentin +ve. | ||
*Cyclin D1 +ve/-ve.<ref name=pmid23771380>{{Cite journal | last1 = Sarma | first1 = NH. | last2 = Arora | first2 = KS. | last3 = Varalaxmi | first3 = KP. | title = Intranodal palisaded myofibroblastoma: a case report and an update on etiopathogenesis and differential diagnosis. | journal = J Cancer Res Ther | volume = 9 | issue = 2 | pages = 295-8 | month = | year = | doi = 10.4103/0973-1482.113395 | PMID = 23771380 }}</ref> | |||
Other: | Other: | ||
| Line 107: | Line 93: | ||
*Desmin -ve | *Desmin -ve | ||
*Ki-67 - low. | *Ki-67 - low. | ||
*HMB-45 -ve. | |||
==See also== | ==See also== | ||