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Difference between revisions of "Leiomyoma"
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** Fascicular appearance: adjacent groups of cells have their long axis perpendicular to one another; looks somewhat like a braided hair that was cut. | ** Fascicular appearance: adjacent groups of cells have their long axis perpendicular to one another; looks somewhat like a braided hair that was cut. | ||
* Whorled arrangement of cells. | * Whorled arrangement of cells. | ||
* Often arise from a muscular artery -- medium-sized artery seen at the periphery of the lesion. | |||
Uncommonly present - see note: | Uncommonly present - see note: | ||
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===Variants=== | ===Variants=== | ||
*Lipoleiomyoma - with adipose tissue. | *Lipoleiomyoma - with adipose tissue. | ||
*Hypercellular leiomyoma - hypercellularity assoc. with more mutations.<ref>[http://www3.interscience.wiley.com/journal/119360394/abstract http://www3.interscience.wiley.com/journal/119360394/abstract]</ref> | *Hypercellular leiomyoma - hypercellularity assoc. with more mutations.<ref>[http://www3.interscience.wiley.com/journal/119360394/abstract http://www3.interscience.wiley.com/journal/119360394/abstract]</ref> | ||
*Atypical leiomyoma ([[AKA]] ''symplastic leiomyoma'') - leiomyoma with nuclear atypia. | *Atypical leiomyoma ([[AKA]] ''symplastic leiomyoma'') - leiomyoma with nuclear atypia. | ||
*Benign metastasizing leiomyoma.<ref>{{Cite journal | last1 = Patton | first1 = KT. | last2 = Cheng | first2 = L. | last3 = Papavero | first3 = V. | last4 = Blum | first4 = MG. | last5 = Yeldandi | first5 = AV. | last6 = Adley | first6 = BP. | last7 = Luan | first7 = C. | last8 = Diaz | first8 = LK. | last9 = Hui | first9 = P. | title = Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis. | journal = Mod Pathol | volume = 19 | issue = 1 | pages = 130-40 | month = Jan | year = 2006 | doi = 10.1038/modpathol.3800504 | PMID = 16357844 |url=http://www.nature.com/modpathol/journal/v19/n1/full/3800504a.html}}</ref> | *Benign metastasizing leiomyoma.<ref>{{Cite journal | last1 = Patton | first1 = KT. | last2 = Cheng | first2 = L. | last3 = Papavero | first3 = V. | last4 = Blum | first4 = MG. | last5 = Yeldandi | first5 = AV. | last6 = Adley | first6 = BP. | last7 = Luan | first7 = C. | last8 = Diaz | first8 = LK. | last9 = Hui | first9 = P. | title = Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis. | journal = Mod Pathol | volume = 19 | issue = 1 | pages = 130-40 | month = Jan | year = 2006 | doi = 10.1038/modpathol.3800504 | PMID = 16357844 |url=http://www.nature.com/modpathol/journal/v19/n1/full/3800504a.html}}</ref> | ||
**This is just what it sounds like. Some believe these are low grade [[leiomyosarcoma]]s. | **This is just what it sounds like. Some believe these are low grade [[leiomyosarcoma]]s. | ||
<gallery> | |||
Image:Atypical_leiomyoma_intermed_mag.jpg | Atypical leiomyoma. (WC/Nephron) | |||
Image:Lipoleiomyoma1.jpg | Lipoleiomyoma - low mag. (WC/Nephron) | |||
</gallery> | |||
==IHC== | ==IHC== | ||