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*Classically thought to be only due to ''Neisseria meningitidis''; however, more recently also associated with ''Streptococcus aureus''.<ref name=pmid16177250>{{cite journal |author=Adem PV, Montgomery CP, Husain AN, ''et al.'' |title=Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children |journal=N. Engl. J. Med. |volume=353 |issue=12 |pages=1245–51 |year=2005 |month=September |pmid=16177250 |doi=10.1056/NEJMoa044194 |url=}}</ref><ref name=pmid14747454>{{cite journal |author=Hamilton D, Harris MD, Foweraker J, Gresham GA |title=Waterhouse-Friderichsen syndrome as a result of non-meningococcal infection |journal=J. Clin. Pathol. |volume=57 |issue=2 |pages=208–9 |year=2004 |month=February |pmid=14747454 |pmc=1770213 |doi= |url=}}</ref> | *Classically thought to be only due to ''Neisseria meningitidis''; however, more recently also associated with ''Streptococcus aureus''.<ref name=pmid16177250>{{cite journal |author=Adem PV, Montgomery CP, Husain AN, ''et al.'' |title=Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children |journal=N. Engl. J. Med. |volume=353 |issue=12 |pages=1245–51 |year=2005 |month=September |pmid=16177250 |doi=10.1056/NEJMoa044194 |url=}}</ref><ref name=pmid14747454>{{cite journal |author=Hamilton D, Harris MD, Foweraker J, Gresham GA |title=Waterhouse-Friderichsen syndrome as a result of non-meningococcal infection |journal=J. Clin. Pathol. |volume=57 |issue=2 |pages=208–9 |year=2004 |month=February |pmid=14747454 |pmc=1770213 |doi= |url=}}</ref> | ||
==Gross== | ===Gross=== | ||
Features: | Features: | ||
*Massive haemorrhage within the substance of the adrenal gland. | *Massive haemorrhage within the substance of the adrenal gland. | ||
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*Post-mortem changes. | *Post-mortem changes. | ||
==Microscopic== | ===Microscopic=== | ||
Features: | Features: | ||
*Massive haemorrhage within the substance of the adrenal gland. | *Massive haemorrhage within the substance of the adrenal gland. |
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