Difference between revisions of "Kidney tumours"

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Kidney tumours (view source)

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=Tabular comparison (selected tumours)=  
=Tabular comparison (selected tumours)=  


Selected common tumours of the kidney:<ref>{{Ref GUP|281-304}}</ref><ref name=pmid19494850>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue =  | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 }}</ref>
Selected common tumours of the kidney:<ref name=Ref_GUP281>{{Ref GUP|281-304}}</ref><ref name=pmid19494850>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue =  | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 }}</ref>
{| class="wikitable"
{| class="wikitable"
|
|
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|-
|-
|Image(s)
|Image(s)
| [http://commons.wikimedia.org/wiki/File:Renal_clear_cell_ca_%281%29_Nephrectomy.jpg CCRCC (WC)]
| [[Image:Renal_clear_cell_ca_%281%29_Nephrectomy.jpg|thumb|150px| CCRCC (WC)]]
| [http://commons.wikimedia.org/wiki/File:Papillary_renal_cell_carcinoma_intermed_mag.jpg PaRCC - intermed. (WC)], [http://commons.wikimedia.org/wiki/File:Papillary_renal_cell_carcinoma_very_high_mag.jpg PaRCC - high (WC)]
| [[Image:Papillary_renal_cell_carcinoma_intermed_mag.jpg|thumb|150px| PaRCC - intermed. (WC)]], [[Image:Papillary_renal_cell_carcinoma_very_high_mag.jpg | thumb|150px| PaRCC - high (WC)]]
|
|
|
|
| [http://commons.wikimedia.org/wiki/File:Oncocytic_chromophobe_rcc_high_mag.jpg ChRCC (WC)]
| [[Image:Oncocytic_chromophobe_rcc_high_mag.jpg|thumb|150px| ChRCC (WC)]]
| [http://commons.wikimedia.org/wiki/File:Renal_oncocytoma2.jpg Oncocytoma (WC)]
| [[Image:Renal_oncocytoma2.jpg|thumb|150px| Oncocytoma (WC)]]
|}
|}
Notes:
Notes:
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|-
|-
| Image
| Image
| [http://commons.wikimedia.org/wiki/File:Oncocytic_chromophobe_rcc_high_mag.jpg ChRCC (WC)]
| [[Image:Oncocytic_chromophobe_rcc_high_mag.jpg |thumb|150px|ChRCC (WC/Nephron)]]
| [http://commons.wikimedia.org/wiki/File:Renal_oncocytoma2.jpg Oncocytoma (WC)]
| [[Image:Renal_oncocytoma2.jpg |thumb|150px|Oncocytoma (WC/Nephron)]]
|}
|}


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*[[Adrenal gland]], normal.
*[[Adrenal gland]], normal.


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Clear_cell_renal_cell_carcinoma_intermed_mag.jpg CRCC - intermed. mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Clear_cell_renal_cell_carcinoma_high_mag.jpg CRCC - high mag. (WC)].
Image:Clear_cell_renal_cell_carcinoma_intermed_mag.jpg | CRCC - intermed. mag. (WC/Nephron)
 
Image:Clear_cell_renal_cell_carcinoma_high_mag.jpg | CRCC - high mag. (WC/Nephron)
</gallery>
===IHC===
===IHC===
*CK7 -ve.  
*CK7 -ve.  
Line 619: Line 620:
#*ChRCC has wisps in the cytoplasm.
#*ChRCC has wisps in the cytoplasm.


Image:
====Image====
*[http://commons.wikimedia.org/wiki/File:Oncocytic_chromophobe_rcc_high_mag.jpg Oncocytic chromophobe RCC (WC)].
<gallery>
Image:Oncocytic_chromophobe_rcc_high_mag.jpg | Oncocytic chromophobe RCC. (WC/Nephron)
</gallery>
www:
*[http://path.upmc.edu/cases/case333.html Chromophobe RCC - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case333.html Chromophobe RCC - several images (upmc.edu)].


Line 675: Line 679:
*[[Xp11.2 translocation carcinoma]].
*[[Xp11.2 translocation carcinoma]].


Images:
====Images====
*www:
<gallery>
**[http://path.upmc.edu/cases/case682.html Clear cell papillary RCC - several images (upmc.edu)].
Image:Clear_cell_papillary_renal_cell_carcinoma_-_high_mag.jpg | CCPRCC - high mag. (WC/Nephron)
**[http://www.flickr.com/photos/40764007@N08/7177459461/ CCPRCC (flickr.com)].
Image:Clear_cell_papillary_renal_cell_carcinoma_-_very_high_mag.jpg | CCPRCC - very high mag. (WC/Nephron)
*[[WC]]:
</gallery>
**[http://commons.wikimedia.org/wiki/File:Clear_cell_papillary_renal_cell_carcinoma_-_high_mag.jpg CCPRCC - high mag. (WC)].
www:
**[http://commons.wikimedia.org/wiki/File:Clear_cell_papillary_renal_cell_carcinoma_-_very_high_mag.jpg CCPRCC - very high mag. (WC)].
*[http://path.upmc.edu/cases/case682.html Clear cell papillary RCC - several images (upmc.edu)].
 
*[http://www.flickr.com/photos/40764007@N08/7177459461/ CCPRCC (flickr.com)].
===IHC===
===IHC===
Features:<ref name=pmid21602815/>
Features:<ref name=pmid21602815/>
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*Epithelioid angiomyolipoma.
*Epithelioid angiomyolipoma.


Images:
====Images====
*[[WC]]:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Xp11.2_translocation_renal_cell_carcinoma_-_intermed_mag.jpg Xp11.2 translocation RCC - intermed. mag. (WC)].
Image:Xp11.2_translocation_renal_cell_carcinoma_-_intermed_mag.jpg | Xp11.2 translocation RCC - intermed. mag. (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Xp11.2_translocation_renal_cell_carcinoma_-_high_mag.jpg Xp11.2 translocation RCC - high mag. (WC)].
Image:Xp11.2_translocation_renal_cell_carcinoma_-_high_mag.jpg | Xp11.2 translocation RCC - high mag. (WC/Nephron)
*www:
</gallery>
**[http://www.flickr.com/photos/40764007@N08/7403237732/in/photostream/ Translocation carcinoma (flickr.com)].
www:
*[http://www.flickr.com/photos/40764007@N08/7403237732/in/photostream/ Translocation carcinoma (flickr.com)].


===IHC===
===IHC===
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*1/3 have a characteristic central scar.<ref name=Ref_GUP302>{{Ref GUP|302}}</ref>
*1/3 have a characteristic central scar.<ref name=Ref_GUP302>{{Ref GUP|302}}</ref>


Image:
====Image====
*[http://en.wikipedia.org/wiki/File:Renal_oncocytoma.jpg Renal oncocytoma with central scar (WP)].
<gallery>
 
Image:Renal_oncocytoma.jpg| Renal oncocytoma with central scar. (WP)
</gallery>
===Microscopic===
===Microscopic===
Features:
Features:
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*[[Clear cell renal cell carcinoma]], eosinophilic variant.
*[[Clear cell renal cell carcinoma]], eosinophilic variant.


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Renal_oncocytoma2.jpg High mag. oncocytoma (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Renal_oncocytoma3.jpg Intermed. mag. oncocytoma (WC)].
Image:Renal_oncocytoma2.jpg | Oncocytoma - high mag. (WC/Nephron)
*[http://commons.wikimedia.org/wiki/File:Renal_oncocytoma4.jpg Low mag. oncocytoma (WC)].
Image:Renal_oncocytoma3.jpg | Oncocytoma - intermed. mag. (WC/Nephron)
 
Image:Renal_oncocytoma4.jpg | Oncocytoma - low mag. (WC/Nephron)
</gallery>
===Stains===
===Stains===
*[[Hale's colloidal iron]] -ve  
*[[Hale's colloidal iron]] -ve  
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*[[Interstitial nephritis]].
*[[Interstitial nephritis]].


Image:
====Image====
*[http://commons.wikimedia.org/wiki/File:Xanthogranulomatous_pyelonephritis_cd68.jpg Xanthogranulomatous pyelonephritis - CD68 IHC (WC)].
<gallery>
 
Image:Xanthogranulomatous_pyelonephritis_cd68.jpg | Xanthogranulomatous pyelonephritis - CD68 stain. (WC/Nephron)
</gallery>
===Stains===
===Stains===
*[[PAS-D]] -ve.
*[[PAS-D]] -ve.
Line 1,021: Line 1,029:
*+/-Entrapped renal tubules.<ref name=pmid12066202>{{Cite journal  | last1 = Kuroda | first1 = N. | last2 = Toi | first2 = M. | last3 = Miyazaki | first3 = E. | last4 = Hayashi | first4 = Y. | last5 = Nakayama | first5 = H. | last6 = Hiroi | first6 = M. | last7 = Enzan | first7 = H. | title = Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors. | journal = Oncol Rep | volume = 9 | issue = 4 | pages = 745-50 | month =  | year =  | doi =  | PMID = 12066202 }}</ref>
*+/-Entrapped renal tubules.<ref name=pmid12066202>{{Cite journal  | last1 = Kuroda | first1 = N. | last2 = Toi | first2 = M. | last3 = Miyazaki | first3 = E. | last4 = Hayashi | first4 = Y. | last5 = Nakayama | first5 = H. | last6 = Hiroi | first6 = M. | last7 = Enzan | first7 = H. | title = Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors. | journal = Oncol Rep | volume = 9 | issue = 4 | pages = 745-50 | month =  | year =  | doi =  | PMID = 12066202 }}</ref>


Images:
====Images====
*www:
<gallery>
**[http://webpathology.com/image.asp?case=71&n=15 Renomedullary interstitial cell tumour - low mag. (webpathology.com)].
Image:Renal_medullary_fibroma_-_low_mag.jpg | Renal medullary fibroma - low mag. (WC/Nephron)
**[http://webpathology.com/image.asp?n=16&Case=71 Renomedullary interstitial cell tumour - high mag. (webpathology.com)].
Image:Renal_medullary_fibroma_-_intermed_mag.jpg | Renal medullary fibroma - intermed. mag. (WC/Nephron)
*[[WC]]:
Image:Renal_medullary_fibroma_-_very_high_mag.jpg | Renal medullary fibroma - very high mag. (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Renal_medullary_fibroma_-_low_mag.jpg Renal medullary fibroma - low mag. (WC)].
</gallery>
**[http://commons.wikimedia.org/wiki/File:Renal_medullary_fibroma_-_intermed_mag.jpg Renal medullary fibroma - intermed. mag. (WC)].
www:
**[http://commons.wikimedia.org/wiki/File:Renal_medullary_fibroma_-_very_high_mag.jpg Renal medullary fibroma - very high mag. (WC)].
*[http://webpathology.com/image.asp?case=71&n=15 Renomedullary interstitial cell tumour - low mag. (webpathology.com)].
 
*[http://webpathology.com/image.asp?n=16&Case=71 Renomedullary interstitial cell tumour - high mag. (webpathology.com)].
==Metanephric adenoma==
==Metanephric adenoma==
*Should '''not''' be confused ''[[mesonephric adenoma]]'', another term for ''nephrogenic adenoma''.
*Should '''not''' be confused ''[[mesonephric adenoma]]'', another term for ''nephrogenic adenoma''.
Line 1,054: Line 1,062:
*[[Papillary renal cell carcinoma|Papillary RCC]].<ref name=Ref_WMSP284>{{Ref WMSP|284}}</ref>
*[[Papillary renal cell carcinoma|Papillary RCC]].<ref name=Ref_WMSP284>{{Ref WMSP|284}}</ref>


Images:
====Images====
*www:
<gallery>
**[http://www.nature.com/modpathol/journal/v16/n10/fig_tab/3880886f1.html Metanephric adenoma (nature.com)].
Image:Metanephric_adenoma_high_mag.jpg | Metanephric adenoma (WC/Nephron)
*[[WC]]:
Image:Metanephric_adenoma_high_mag_cropped.jpg | Metanephric adenoma - cropped (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Metanephric_adenoma_high_mag.jpg Metanephric adenoma (WC)].
Image:Metanephric_adenoma_-_intermed_mag.jpg | Metanephric adenoma - PaRCC-like - intermed. mag. (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Metanephric_adenoma_high_mag_cropped.jpg Metanephric adenoma - cropped (WC)].
Image:Metanephric_adenoma_-_very_high_mag.jpg | Metanephric adenoma - PaRCC-like - very high mag. (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Metanephric_adenoma_-_intermed_mag.jpg Metanephric adenoma - PaRCC-like - intermed. mag. (WC)].
</gallery>
**[http://commons.wikimedia.org/wiki/File:Metanephric_adenoma_-_very_high_mag.jpg Metanephric adenoma - PaRCC-like - very high mag. (WC)].
www:
 
*[http://www.nature.com/modpathol/journal/v16/n10/fig_tab/3880886f1.html Metanephric adenoma (nature.com)].
===IHC===
===IHC===
*WT-1 +ve.
*WT-1 +ve.
Line 1,098: Line 1,106:
*Parenchymal elements (e.g. glomueruli, tubules) are not found in the septa between the cysts.
*Parenchymal elements (e.g. glomueruli, tubules) are not found in the septa between the cysts.


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Cystic_nephroma_low_mag.jpg Cystic nephroma - low mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Cystic_nephroma_intermed_mag.jpg Cystic nephroma - intermed. mag. (WC)].
Image:Cystic_nephroma_low_mag.jpg |Cystic nephroma - low mag. (WC/Nephron)
 
Image:Cystic_nephroma_intermed_mag.jpg |Cystic nephroma - intermed. mag. (WC/Nephron)
</gallery>
===IHC===
===IHC===
Features:<ref name=pmid17454754>{{Cite journal  | last1 = Mai | first1 = KT. | last2 = Elkeilani | first2 = A. | last3 = Veinot | first3 = JP. | title = Mixed epithelial and stromal tumour (MEST) of the kidney: report of 14 cases with male and PEComatous variants and proposed histopathogenesis. | journal = Pathology | volume = 39 | issue = 2 | pages = 235-40 | month = Apr | year = 2007 | doi = 10.1080/00313020701230799 | PMID = 17454754 }}
Features:<ref name=pmid17454754>{{Cite journal  | last1 = Mai | first1 = KT. | last2 = Elkeilani | first2 = A. | last3 = Veinot | first3 = JP. | title = Mixed epithelial and stromal tumour (MEST) of the kidney: report of 14 cases with male and PEComatous variants and proposed histopathogenesis. | journal = Pathology | volume = 39 | issue = 2 | pages = 235-40 | month = Apr | year = 2007 | doi = 10.1080/00313020701230799 | PMID = 17454754 }}
Line 1,121: Line 1,130:
*Bubble wrap-like appearance.
*Bubble wrap-like appearance.


Image:
====Image====
*[http://commons.wikimedia.org/wiki/File:Bubble_Wrap.jpg Bubble wrap (WC)].
<gallery>
 
Image:Bubble_Wrap.jpg| Bubble wrap. (WC)
</gallery>
===Microscopic===
===Microscopic===
Features:
Features:
Line 1,133: Line 1,143:
Notes:
Notes:
*Parenchymal elements (e.g. glomueruli, tubules) are not found in the septa between the cysts.
*Parenchymal elements (e.g. glomueruli, tubules) are not found in the septa between the cysts.
 
====Images====
Images:
<gallery>
*[http://commons.wikimedia.org/wiki/File:Cystic_nephroma_low_mag.jpg Cystic nephroma - low mag. (WC)].
Image:Cystic_nephroma_low_mag.jpg |Cystic nephroma - low mag. (WC/Nephron)
*[http://commons.wikimedia.org/wiki/File:Cystic_nephroma_intermed_mag.jpg Cystic nephroma - intermed. mag. (WC)].
Image:Cystic_nephroma_intermed_mag.jpg |Cystic nephroma - intermed. mag. (WC/Nephron)
</gallery>


===IHC===
===IHC===
Michael
48,833

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