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**Organ transplant recipients. | **Organ transplant recipients. | ||
**[[HIV|HIV/AIDS]]. | **[[HIV|HIV/AIDS]]. | ||
Images: | |||
<gallery> | |||
Image:CMV_colitis_-_high_mag_-_cropped.jpg | CMV colitis - high. mag. (WC/Nephron) | |||
Image:CMV_colitis_-_intermed_mag.jpg | CMV colitis - intermed. mag. (WC/Nephron) | |||
</gallery> | |||
=Grossing= | =Grossing= | ||
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Most common (images): | Most common (images): | ||
<gallery> | |||
Image:Hyperplastic_polyp1.jpg | Hyperplastic polyp image - intermed. mag. (WC/Nephron) | |||
Image:Hyperplastic_polyp2.jpg | Hyperplastic polyp image - low mag. (WC/Nephron) | |||
</gallery> | |||
==Ischemic colitis== | ==Ischemic colitis== | ||
*[[AKA]] ''colonic ischemia''. | *[[AKA]] ''colonic ischemia''. | ||
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*Wall thickening (reactive).<ref name=pmid21359889>{{Cite journal | last1 = Nicholson | first1 = BD. | last2 = Hyland | first2 = R. | last3 = Rembacken | first3 = BJ. | last4 = Denyer | first4 = M. | last5 = Hull | first5 = MA. | last6 = Tolan | first6 = DJ. | title = Colonoscopy for colonic wall thickening at computed tomography: a worthwhile pursuit? | journal = Surg Endosc | volume = 25 | issue = 8 | pages = 2586-91 | month = Aug | year = 2011 | doi = 10.1007/s00464-011-1591-7 | PMID = 21359889 }}</ref> | *Wall thickening (reactive).<ref name=pmid21359889>{{Cite journal | last1 = Nicholson | first1 = BD. | last2 = Hyland | first2 = R. | last3 = Rembacken | first3 = BJ. | last4 = Denyer | first4 = M. | last5 = Hull | first5 = MA. | last6 = Tolan | first6 = DJ. | title = Colonoscopy for colonic wall thickening at computed tomography: a worthwhile pursuit? | journal = Surg Endosc | volume = 25 | issue = 8 | pages = 2586-91 | month = Aug | year = 2011 | doi = 10.1007/s00464-011-1591-7 | PMID = 21359889 }}</ref> | ||
Endoscopic image: | Endoscopic image: <gallery>Image:Diverticulosis_2.jpg | DD (WC)</gallery> | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
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Images: | Images: | ||
*[http://en.wikipedia.org/wiki/File:PMC_1.jpg Pseudomembranous colitis - endoscopic image (WP/Samir)]. | *[http://en.wikipedia.org/wiki/File:PMC_1.jpg Pseudomembranous colitis - endoscopic image (WP/Samir)]. | ||
<gallery> | |||
Image:Pseudomembranous_colitis.JPG | Pseudomembranous colitis (WC/Nephron) | |||
</gallery> | |||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=Ref_PBoD837-8>{{Ref PBoD|837-8}}</ref> | Features:<ref name=Ref_PBoD837-8>{{Ref PBoD|837-8}}</ref> | ||
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*Rarely have (benign) [[signet ring cell]]-like cells.<ref name=pmid12684766>{{Cite journal | last1 = Abdulkader | first1 = I. | last2 = Cameselle-Teijeiro | first2 = J. | last3 = Forteza | first3 = J. | title = Signet-ring cells associated with pseudomembranous colitis. | journal = Virchows Arch | volume = 442 | issue = 4 | pages = 412-4 | month = Apr | year = 2003 | doi = 10.1007/s00428-003-0779-1 | PMID = 12684766 }}</ref> | *Rarely have (benign) [[signet ring cell]]-like cells.<ref name=pmid12684766>{{Cite journal | last1 = Abdulkader | first1 = I. | last2 = Cameselle-Teijeiro | first2 = J. | last3 = Forteza | first3 = J. | title = Signet-ring cells associated with pseudomembranous colitis. | journal = Virchows Arch | volume = 442 | issue = 4 | pages = 412-4 | month = Apr | year = 2003 | doi = 10.1007/s00428-003-0779-1 | PMID = 12684766 }}</ref> | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Colonic_pseudomembranes_low_mag.jpg Micrograph of pseudomembranes - low mag. (WC/Nephron) | |||
Image:Colonic_pseudomembranes_intermed_mag.jpg Micrograph of pseudomembranes - intermed. mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case153.html Pseudomembranous colitis (upmc.edu)]. | |||
==Volvulus== | ==Volvulus== | ||
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*Should not be diagnosed in the cecum - as it (normally) has a thickened subepithelial collagen band.{{fact}} | *Should not be diagnosed in the cecum - as it (normally) has a thickened subepithelial collagen band.{{fact}} | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Collagenous_colitis_-_intermed_mag.jpg | CC - intermed mag. (WC/Nephron) | |||
Image:Collagenous_colitis_-_high_mag.jpg Collagenous colitis - high mag. (WC/Nephron) | |||
</gallery> | |||
===Sign out=== | ===Sign out=== | ||
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**[[Pseudomembranous colitis]]. | **[[Pseudomembranous colitis]]. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Diversion_proctitis_-_low_mag.jpg | Diversion proctitis - low mag. (WC/Nephron) | |||
Image:Diversion_proctitis_-_high_mag.jpg | Diversion proctitis - high mag. (WC/Nephron) | |||
</gallery> | |||
===Sign out=== | ===Sign out=== | ||
<pre> | <pre> | ||
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*CMV colitis superimposed on [[inflammatory bowel disease]]. | *CMV colitis superimposed on [[inflammatory bowel disease]]. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:CMV_colitis_-_intermed_mag.jpg | CMV colitis - intermed. mag. (WC/Nephron) | |||
Image:CMV_colitis_-_high_mag_-_cropped.jpg | CMV colitis - high mag. (WC/Nephron) | |||
</gallery> | |||
===IHC=== | ===IHC=== | ||
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*[[Infectious colitis]] without a distinctive morphology. | *[[Infectious colitis]] without a distinctive morphology. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Intestinal_spirochetosis_-_cropped_-_very_high_mag.jpg | Intestinal spirochetes - cropped - very high mag. (WC/Nephron) | |||
Image:Intestinal_spirochetosis_-_very_high_mag.jpg | Intestinal spirochetes - very high mag. (WC/Nephron) | |||
Image:Intestinal_spirochetosis_-_intermed_mag.jpg | Intestinal spirochetes - intermed. mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case391.html Intestinal spirochetosis & CMV colitis - several images (upmc.edu)]. | |||
===Special stains=== | ===Special stains=== | ||
*Silver stains highlight 'em (e.g. Warthin-Starry stain). | *Silver stains highlight 'em (e.g. Warthin-Starry stain). | ||
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**Ingest [[RBC]]s. | **Ingest [[RBC]]s. | ||
Image | ====Image==== | ||
<gallery> | |||
Image:Amebiasis_-_very_high_mag.jpg | Amebiasis - very high mag. (WC/Nephron) | |||
Image:Amoebic_dysentery_in_colon_biopsy_%281%29.jpg | Amebiasis (WC) | |||
</gallery> | |||
==Cryptosporidiosis== | ==Cryptosporidiosis== | ||
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*'''Important negative''': no nuclear atypia. | *'''Important negative''': no nuclear atypia. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Rectal_prolapse_-_low_mag.jpg | Rectal prolapse - low mag. (WC/Nephon) | |||
Image:Rectal_prolapse_-_intermed_mag.jpg | Rectal prolapse - intermed. mag. (WC/Nephron) | |||
</gallery> | |||
=Neoplastic disease= | =Neoplastic disease= | ||
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*Brown pigmentation of the mucosa, esp. cecum and proximal colon. | *Brown pigmentation of the mucosa, esp. cecum and proximal colon. | ||
Image | ====Image==== | ||
<gallery> | |||
Image:Melanosis_coli.jpg | Melanosis coli - endoscopic image (WC) | |||
</gallery> | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Brown granular pigment - in the lamina propria. | *Brown granular pigment - in the lamina propria. | ||
**Typically more prominent in the cecum and proximal colon.<ref name=pmid18666316/> | **Typically more prominent in the cecum and proximal colon.<ref name=pmid18666316/> | ||
Notes: | Notes: | ||
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**Foreign material (e.g. tattoo pigment) - not seen in GI tract. | **Foreign material (e.g. tattoo pigment) - not seen in GI tract. | ||
====Images==== | |||
<gallery> | |||
Image:Melanosis_coli_high_mag.jpg | Melanosis coli - high mag. (WC/Nephron) | |||
Image:Melanosis_coli_low_mag.jpg | Melanosis coli - low mag. (WC/Nephron) | |||
</gallery> | |||
===Stains=== | ===Stains=== | ||
*Can be demonstrated with a [[PAS stain]].<ref name=pmid9283862>{{cite journal |author=Benavides SH, Morgante PE, Monserrat AJ, Zárate J, Porta EA |title=The pigment of melanosis coli: a lectin histochemical study |journal=Gastrointest. Endosc. |volume=46 |issue=2 |pages=131–8 |year=1997 |month=August |pmid=9283862 |doi= |url=}}</ref> | *Can be demonstrated with a [[PAS stain]].<ref name=pmid9283862>{{cite journal |author=Benavides SH, Morgante PE, Monserrat AJ, Zárate J, Porta EA |title=The pigment of melanosis coli: a lectin histochemical study |journal=Gastrointest. Endosc. |volume=46 |issue=2 |pages=131–8 |year=1997 |month=August |pmid=9283862 |doi= |url=}}</ref> | ||
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*Can cause focal [[necrosis]]. | *Can cause focal [[necrosis]]. | ||
Image | =====Image===== | ||
<gallery> | |||
Image:Cecal_adenocarcinoma.jpg | Adenocarcinoma and sodium polystyrene crystals (WC/Nephron) | |||
</gallery> | |||
==Graft-versus host disease== | ==Graft-versus host disease== | ||
{{Main|Graft-versus-host disease}} | {{Main|Graft-versus-host disease}} |
edits