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Difference between revisions of "Leiomyosarcoma"
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**Whorled look at low power. | **Whorled look at low power. | ||
**Groups of spindle cells cut peripendicular to their long axis adjacent to groups of spindle cells cut in the plane of their long axis. | **Groups of spindle cells cut peripendicular to their long axis adjacent to groups of spindle cells cut in the plane of their long axis. | ||
*Features of malignancy (usually need 2 of 3): | *Features of malignancy (usually need 2 of 3): † | ||
*#Nuclear atypia. | *#Nuclear atypia. | ||
*#Tumour cell necrosis. | *#Tumour cell necrosis. | ||
| Line 32: | Line 32: | ||
Notes: | Notes: | ||
*† In deep soft tissue. 1 of 3 criteria is considered enough.<ref>URL: [http://surgpathcriteria.stanford.edu/softsmoothmuscle/soft_tissue_leiomyosarcoma/differentialdiagnosis.html http://surgpathcriteria.stanford.edu/softsmoothmuscle/soft_tissue_leiomyosarcoma/differentialdiagnosis.html]. Accessed on: 10 May 2013.</ref> | |||
*Leiomyosarcoma ''de facto'' trumps other sarcomas.<ref name=pmid22833086/> | *Leiomyosarcoma ''de facto'' trumps other sarcomas.<ref name=pmid22833086/> | ||
*Mitotic rate seems to be a relatively weak predictor; modest rate may be malignant and a high rate benign.<ref name=pmid9388868>{{Cite journal | last1 = Guo | first1 = L. | last2 = Liu | first2 = T. | last3 = Huang | first3 = H. | title = [Reappraisal of the pathological criteria for uterine leiomyosarcoma]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 25 | issue = 5 | pages = 266-9 | month = Oct | year = 1996 | doi = | PMID = 9388868 }}</ref> | *Mitotic rate seems to be a relatively weak predictor; modest rate may be malignant and a high rate benign.<ref name=pmid9388868>{{Cite journal | last1 = Guo | first1 = L. | last2 = Liu | first2 = T. | last3 = Huang | first3 = H. | title = [Reappraisal of the pathological criteria for uterine leiomyosarcoma]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 25 | issue = 5 | pages = 266-9 | month = Oct | year = 1996 | doi = | PMID = 9388868 }}</ref> | ||