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*Candidiasis. | *Candidiasis. | ||
*CMV esophagitis. | *CMV esophagitis. | ||
===Tabular summary=== | |||
{| class="wikitable" | |||
|'''Entity''' | |||
|'''Key feature''' | |||
|'''Other features''' | |||
|'''IHC/Special''' | |||
|'''Clinical''' | |||
|'''Image''' | |||
|- | |||
|Normal | |||
| squamous epi. matures to surface | |||
| no inflammation, no atypia | |||
| - | |||
| - | |||
| [http://commons.wikimedia.org/wiki/File:Tinci%C3%B3n_hematoxilina-eosina.jpg] | |||
|- | |||
|GERD | |||
| inflammation (eosinophils, lymphocytes) | |||
| elongated (epithelial) papillae, basal cell hyperplasia | |||
| | |||
| incr. risk of Barrett's | |||
| | |||
|- | |||
|Eosinophilic esophagitis | |||
| abundant eosinophils | |||
| elongated (epithelial) papillae, basal cell hyperplasia, lymphocytes | |||
| | |||
| unresponsive to PPIs | |||
| [http://en.wikipedia.org/wiki/File:Eosinophilic_esophagiits_path.jpg microscopic], [http://en.wikipedia.org/wiki/File:Eosinophilic_esophagiits_path.jpg endoscopic] | |||
|- | |||
|Barrett's type change | |||
| goblet cells | |||
| no dysplasia | |||
| Alcian blue +ve | |||
| incr. risk of adenocarcinoma | |||
| [http://commons.wikimedia.org/wiki/File:Barretts_alcian_blue.jpg] | |||
|- | |||
|Dysplasia, low grade | |||
| nuclear crowding at surface | |||
| hyperchromasia, mild arch. complexity | |||
| | |||
| incr. risk of carcinoma | |||
| | |||
|- | |||
|Dysplasia, high grade | |||
| cribriforming | |||
| marked nuc. crowding, hyperchromasia | |||
| | |||
| marked incr. risk of carcinoma | |||
| | |||
<!-- | |||
|Entity | |||
|Key feature | |||
|Other features | |||
|IHC | |||
|Clinical | |||
|Image | |||
|- | |||
--> | |||
|} | |||
==Indications== | ==Indications== |
edits