Difference between revisions of "Testis"

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18 bytes added ,  15:23, 18 May 2010
re-order elements
m (→‎IHC: sm fix)
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==Normal==
==Normal==
Tubules
===Seminiferous tubules===
*Sertoli cells (aka sustentacular cell aka nurse cell).  
*Sertoli cells (aka sustentacular cell aka nurse cell).  
**Large cells with oval nucleus.  
**Large cells with oval nucleus.  
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*D2-40 - seminoma.
*D2-40 - seminoma.


==Intratubular germ cell neoplasia==
*Considered the precursor lesion for germ cell tumours.
*Not all germ cell tumours (GCTs) arise from ''intratubular germ cell neoplasia''.
The following testicular GCTs do not arise from ITCGN:
*[[Spermatocytic seminoma]].<ref>{{cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= |url=}}</ref>
*[[Yolk sac tumour]]s (endodermal sinus tumour).<ref>{{cite journal |author=Manivel JC, Simonton S, Wold LE, Dehner LP |title=Absence of intratubular germ cell neoplasia in testicular yolk sac tumors in children. A histochemical and immunohistochemical study |journal=Arch. Pathol. Lab. Med. |volume=112 |issue=6 |pages=641–5 |year=1988 |month=June |pmid=2837162 |doi= |url=}}</ref>
*Teratoma. (???)


==Seminoma==
==Seminoma==
Male counterpart of the [[dysgerminoma]], which arise in the [[ovary]].
*Male counterpart of the [[dysgerminoma]], which arise in the [[ovary]].
 
===Epi. & etiology===
*Arises from ''intratubular germ cell neoplasia'' (ITGCN).


===Microsopy===
===Microsopy===
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*Solid variant of yolk sac tumour.
*Solid variant of yolk sac tumour.
**Lacks fibrous septae and lymphocytes.<ref>URL: [http://webpathology.com/image.asp?case=34&n=8 http://webpathology.com/image.asp?case=34&n=8]. Accessed on: March 8, 2010.</ref>
**Lacks fibrous septae and lymphocytes.<ref>URL: [http://webpathology.com/image.asp?case=34&n=8 http://webpathology.com/image.asp?case=34&n=8]. Accessed on: March 8, 2010.</ref>
===Epi. & etiology===
*Arises from ''intratubular germ cell neoplasia'' (ITGCN).


===IHC===
===IHC===
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*CD30+ (??? check ???)
*CD30+ (??? check ???)
*Cytokeratins - (weak focal positivity)  
*Cytokeratins - (weak focal positivity)  
==Intratubular germ cell neoplasia==
*Considered the precursor lesion for germ cell tumours.
*Not all germ cell tumours (GCTs) arise from ''intratubular germ cell neoplasia''.
The following testicular GCTs do not arise from ITCGN:
*[[Spermatocytic seminoma]].<ref>{{cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= |url=}}</ref>
*[[Yolk sac tumour]]s (endodermal sinus tumour).<ref>{{cite journal |author=Manivel JC, Simonton S, Wold LE, Dehner LP |title=Absence of intratubular germ cell neoplasia in testicular yolk sac tumors in children. A histochemical and immunohistochemical study |journal=Arch. Pathol. Lab. Med. |volume=112 |issue=6 |pages=641–5 |year=1988 |month=June |pmid=2837162 |doi= |url=}}</ref>
*Teratoma. (???)


==Spermatocytic seminoma==
==Spermatocytic seminoma==
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===Epidemiology===
===Epidemiology===
*Does NOT arise from ''intratubular germ cell neoplasia'' (ITGCN)<ref>{{cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= 10.1111/j.1365-2605.1987.tb00176.x|url=}}</ref> - '''not''' considered a subtype of seminoma.
*Does NOT arise from ''intratubular germ cell neoplasia'' (ITGCN)<ref>{{cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= 10.1111/j.1365-2605.1987.tb00176.x|url=}}</ref> - '''not''' considered a subtype of seminoma.


==Yolk sac tumour==
==Yolk sac tumour==
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