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Difference between revisions of "Sjögren syndrome"
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→Grading - historical
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It is based on assessing 4 mm<sup>2</sup> area of salivary gland tissue and depends on the abundance and aggregation of lymphocytes as follows:<ref>{{Cite journal | last1 = Chisholm | first1 = DM. | last2 = Mason | first2 = DK. | title = Labial salivary gland biopsy in Sjögren's disease. | journal = J Clin Pathol | volume = 21 | issue = 5 | pages = 656-60 | month = Sep | year = 1968 | doi = | PMID = 5697370 | PMC = 473887 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC473887/?tool=pubmed }}</ref> | It is based on assessing 4 mm<sup>2</sup> area of salivary gland tissue and depends on the abundance and aggregation of lymphocytes as follows:<ref>{{Cite journal | last1 = Chisholm | first1 = DM. | last2 = Mason | first2 = DK. | title = Labial salivary gland biopsy in Sjögren's disease. | journal = J Clin Pathol | volume = 21 | issue = 5 | pages = 656-60 | month = Sep | year = 1968 | doi = | PMID = 5697370 | PMC = 473887 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC473887/?tool=pubmed }}</ref> | ||
{| class="wikitable sortable" | {| class="wikitable sortable" align=left | ||
! | !Chisholm-Mason <br>grade | ||
!Lymphocytes | !Lymphocytes | ||
!Focus score | |||
|- | |- | ||
| 0 | | 0 | ||
| absent | | absent | ||
| 0 | |||
|- | |- | ||
| 1 | | 1 | ||
| slight infiltrate | | slight infiltrate | ||
| 0 | |||
|- | |- | ||
| 2 | | 2 | ||
| moderate infiltrate or less than one focus † | | moderate infiltrate or less than one focus † | ||
| 0 | |||
|- | |- | ||
| 3 | | 3 | ||
| one focus † | | one focus † | ||
| 1 | |||
|- | |- | ||
| 4 | | 4 | ||
| more than one focus † | | more than one focus † | ||
| >1 | |||
|} | |} | ||
† Focus = aggregrate of 50 lymphocytes. | † Focus = aggregrate of 50 lymphocytes. | ||