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Difference between revisions of "Tissue loss"
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''' | In pathology, '''tissue loss''' is when less tissue is identified at microscopy than at the time of gross. It is relatively common in small biopsies. | ||
It is estimated that approximately 27% of cases have a mismatch between the number of pieces seen at [[gross pathology|gross]] and microscopy.<ref name=pmid22129184>{{Cite journal | last1 = Owens | first1 = SR. | last2 = Wiehagen | first2 = L. | last3 = Simmons | first3 = C. | last4 = Sikorova | first4 = A. | last5 = Stewart | first5 = W. | last6 = Kelly | first6 = S. | last7 = Nestler | first7 = R. | last8 = Yousem | first8 = SA. | title = Numerical fidelity of endoscopic biopsy fragments in the processing sequence of a university surgical pathology laboratory. | journal = Arch Pathol Lab Med | volume = 135 | issue = 12 | pages = 1561-4 | month = Dec | year = 2011 | doi = 10.5858/arpa.2011-0020-OA | PMID = 22129184 }}</ref> A tissue gain is seen in approximately 25% of cases and a tissue loss is seen in approximately 7% of cases.<ref name=pmid22129184/> | It is estimated that approximately 27% of cases have a mismatch between the number of pieces seen at [[gross pathology|gross]] and microscopy.<ref name=pmid22129184>{{Cite journal | last1 = Owens | first1 = SR. | last2 = Wiehagen | first2 = L. | last3 = Simmons | first3 = C. | last4 = Sikorova | first4 = A. | last5 = Stewart | first5 = W. | last6 = Kelly | first6 = S. | last7 = Nestler | first7 = R. | last8 = Yousem | first8 = SA. | title = Numerical fidelity of endoscopic biopsy fragments in the processing sequence of a university surgical pathology laboratory. | journal = Arch Pathol Lab Med | volume = 135 | issue = 12 | pages = 1561-4 | month = Dec | year = 2011 | doi = 10.5858/arpa.2011-0020-OA | PMID = 22129184 }}</ref> A tissue gain is seen in approximately 25% of cases and a tissue loss is seen in approximately 7% of cases.<ref name=pmid22129184/> | ||
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*Pseudofragmentation - two piece of tissue appears to be two in the plane of section. | *Pseudofragmentation - two piece of tissue appears to be two in the plane of section. | ||
*[[Tissue floater]]. | *[[Tissue floater]]. | ||
===Work-up=== | |||
:See ''[[tissue floater]]''. | |||
==Possible causes of tissue loss== | ==Possible causes of tissue loss== | ||
*Tissue floated from the slide. | *Tissue floated from the slide. | ||
*Material submitted soluble in the processing medium, e.g. mucous. | *Material submitted is soluble in the processing medium, e.g. mucous. | ||
===Work-up=== | ===Work-up=== | ||