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Difference between revisions of "Prostate cancer"
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==Gross== | ==Gross== | ||
*Prostate cancer is uncommonly apparent | *Prostate cancer is uncommonly apparent on gross. | ||
*Classic location: posterior aspect of the prostate. | |||
===Prostatectomy grossing=== | ===Prostatectomy grossing=== | ||
There is a consensus paper on grossing by the ''ISUP'':<ref name=pmid20834234>{{Cite journal | last1 = Samaratunga | first1 = H. | last2 = Montironi | first2 = R. | last3 = True | first3 = L. | last4 = Epstein | first4 = JI. | last5 = Griffiths | first5 = DF. | last6 = Humphrey | first6 = PA. | last7 = van der Kwast | first7 = T. | last8 = Wheeler | first8 = TM. | last9 = Srigley | first9 = JR. | title = International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 1: specimen handling. | journal = Mod Pathol | volume = 24 | issue = 1 | pages = 6-15 | month = Jan | year = 2011 | doi = 10.1038/modpathol.2010.178 | PMID = 20834234 }}</ref> | |||
*[[Embedding in toto]] is not required. | *[[Embedding in toto]] is not required. | ||
**A study by Epstein suggests it is reasonable to submit all of the posterior aspect and selected sections from the mid portion.<ref name=pmid11381367>{{Cite journal | last1 = Sehdev | first1 = AE. | last2 = Pan | first2 = CC. | last3 = Epstein | first3 = JI. | title = Comparative analysis of sampling methods for grossing radical prostatectomy specimens performed for nonpalpable (stage T1c) prostatic adenocarcinoma. | journal = Hum Pathol | volume = 32 | issue = 5 | pages = 494-9 | month = May | year = 2001 | doi = 10.1053/hupa.2001.24322 | PMID = 11381367 }}</ref> | **A study by Epstein suggests it is reasonable to submit all of the posterior aspect and selected sections from the mid portion.<ref name=pmid11381367>{{Cite journal | last1 = Sehdev | first1 = AE. | last2 = Pan | first2 = CC. | last3 = Epstein | first3 = JI. | title = Comparative analysis of sampling methods for grossing radical prostatectomy specimens performed for nonpalpable (stage T1c) prostatic adenocarcinoma. | journal = Hum Pathol | volume = 32 | issue = 5 | pages = 494-9 | month = May | year = 2001 | doi = 10.1053/hupa.2001.24322 | PMID = 11381367 }}</ref> | ||
*The prostate should be painted -- to mark the margins. | |||
*Sectioning should be done after fixation. | |||
*The prostate should be weighted after fixation and trimming of the seminal vesicles. | |||
*The apex of the prostate and the bladder neck should be sliced-off, sagittally sectioned, and submitted separately on edge (to assess the margin). | |||
Other: | |||
*All fat should associated with lymph nodes should be submitted, as metastases are found in over 5% of tissue not grossly recognized as a lymph node.<ref name=pmid3773097>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Oesterling | first2 = JE. | last3 = Eggleston | first3 = JC. | last4 = Walsh | first4 = PC. | title = Frozen section detection of lymph node metastases in prostatic carcinoma: accuracy in grossly uninvolved pelvic lymphadenectomy specimens. | journal = J Urol | volume = 136 | issue = 6 | pages = 1234-7 | month = Dec | year = 1986 | doi = | PMID = 3773097 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||