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===Microscopic=== | ===Microscopic=== | ||
#Nuclear changes at the surface | #Nuclear changes at the surface of the mucosa - '''key feature'''. | ||
#*Cigar-shaped (elongated) nucleus (usu. length:width > 3:1) | #*Size and shape ''or'' size change: | ||
#** | #**Cigar-shaped (elongated) nucleus (usu. length:width > 3:1) with nuclear hyperchromasia (more blue). | ||
#*Nuclear crowding/pseudostratification - ''' | #**Large round nuclei +/- vesicular appearance (clearing) -- nuclei have white space. | ||
#*Nuclear crowding/pseudostratification - '''important'''. | |||
#*+/-Loss of nuclear polarity (nuclei no longer on basement membrane). | #*+/-Loss of nuclear polarity (nuclei no longer on basement membrane). | ||
#Loss/decrease of goblet cells (common). | #Loss/decrease of goblet cells (common). |
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