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Difference between revisions of "Kidney tumours"
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→Xanthogranulomatous pyelonephritis
(→Microscopic: +low mag) |
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==Xanthogranulomatous pyelonephritis== | ==Xanthogranulomatous pyelonephritis== | ||
===General=== | ===General=== | ||
*May mimic [[RCC]] | *May mimic [[RCC]] - espically radiologically. | ||
*Usually lower pole. (???) | *Usually lower pole. (???) | ||
*Associated with: | *Associated with: | ||
| Line 891: | Line 891: | ||
*Abundant macrophages. | *Abundant macrophages. | ||
*+/-Giant cells. | *+/-Giant cells. | ||
DDx: | |||
*[[Malakoplakia]]. | |||
**Basophilic inclusions -- inside or outside of macrophages - often size of RBC or larger ([[Michaelis-Gutmann bodies]]). | |||
*RCC - especially [[PRCC]] (as this has foamy macrophages). | |||
*Granulomatous disease. | |||
Image: | Image: | ||
*[http://commons.wikimedia.org/wiki/File:Xanthogranulomatous_pyelonephritis_cd68.jpg Xanthogranulomatous pyelonephritis - CD68 IHC (WC)]. | *[http://commons.wikimedia.org/wiki/File:Xanthogranulomatous_pyelonephritis_cd68.jpg Xanthogranulomatous pyelonephritis - CD68 IHC (WC)]. | ||
===Stains=== | |||
*[[PAS-D]] -ve. | |||
**Done to look for malakoplakia. | |||
===IHC=== | ===IHC=== | ||
*CD68 +ve. | *CD68 +ve. | ||
*RCC markers (CD10, RCC) all negative. | *RCC markers (CD10, RCC) all negative. | ||
==Malakoplakia== | ==Malakoplakia== | ||