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Difference between revisions of "Non-malignant skin disease"
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→Molluscum contagiosum
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===General=== | ===General=== | ||
*Etiology: caused by ''molluscum contagiosum virus''. | *Etiology: caused by ''molluscum contagiosum virus''. | ||
*May be abundant in immune deficient individuals, e.g. [[HIV]]/AIDS. | |||
===Gross=== | ===Gross=== | ||
* | Features:<ref name=Ref_Derm115>{{Ref Derm|115}}</ref> | ||
*Dome-shaped papules, flesh coloured or pearly. | |||
*Usually face or trunk. | |||
*+/-Central umbilication. | |||
**Central depression. | |||
DDx - gross: | DDx - gross: | ||
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*A suprabasilar epidermal lesion consisting of "molluscum bodies", i.e. ''molluscum bodies'' are found above the stratum basale.<ref>[http://www.missionforvisionusa.org/anatomy/2006/08/what-is-molluscum-contagiosum.html http://www.missionforvisionusa.org/anatomy/2006/08/what-is-molluscum-contagiosum.html]</ref> | *A suprabasilar epidermal lesion consisting of "molluscum bodies", i.e. ''molluscum bodies'' are found above the stratum basale.<ref>[http://www.missionforvisionusa.org/anatomy/2006/08/what-is-molluscum-contagiosum.html http://www.missionforvisionusa.org/anatomy/2006/08/what-is-molluscum-contagiosum.html]</ref> | ||
*Molluscum bodies - '''key feature''': | *Molluscum bodies - '''key feature''': | ||
**Large cells with | **Large cells with granular eosinophilic cytoplasmic inclusions. | ||
***Inclusions fill the cytoplasm | |||
**Small peripheral nucleus. | **Small peripheral nucleus. | ||
Notes: | Notes: | ||
*Molluscum bodies very vaguely resemble ''[[signet ring cell]]s'' -- but: | *Molluscum bodies very vaguely resemble ''[[signet ring cell]]s'' -- but: | ||
**Cytoplasm eosinophilic and granular. | **Cytoplasm is eosinophilic and granular. | ||
**Nucleus usually smaller than in signet ring cell. | **Nucleus usually smaller than in signet ring cell. | ||
**''Molluscum bodies'' are only the epidermis - an uncommon place to find SRCs without finding them elsewhere. | **''Molluscum bodies'' are only the epidermis - an uncommon place to find SRCs without finding them elsewhere. | ||
*The granular eosinophilic | *The granular eosinophilic cytoplasmic inclusions represents accumulated virons. | ||
DDx: | DDx: | ||
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====Micro==== | ====Micro==== | ||
The section shows fragments of skin with epithelium on three sides. Large suprabasilar cells with eosinophilic | The section shows fragments of skin with epithelium on three sides. Large suprabasilar cells with eosinophilic intracytoplasmic inclusions and eccentric nuclei (molluscum bodies) are present. The epithelium is acanthotic; however, it matures to the surface. There is no significant inflammation. | ||
==Superficial dermal infiltrates== | ==Superficial dermal infiltrates== | ||