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→Ménétrier's disease
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*Increased risk of gastric adenocarcinoma.<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref> | *Increased risk of gastric adenocarcinoma.<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref> | ||
Clinical:<ref>{{Cite journal | last1 = Rich | first1 = A. | last2 = Toro | first2 = TZ. | last3 = Tanksley | first3 = J. | last4 = Fiske | first4 = WH. | last5 = Lind | first5 = CD. | last6 = Ayers | first6 = GD. | last7 = Piessevaux | first7 = H. | last8 = Washington | first8 = MK. | last9 = Coffey | first9 = RJ. | title = Distinguishing Ménétrier's disease from its mimics. | journal = Gut | volume = 59 | issue = 12 | pages = 1617-24 | month = Dec | year = 2010 | doi = 10.1136/gut.2010.220061 | PMID = 20926644 }}</ref> | Clinical:<ref name=pmid20926644>{{Cite journal | last1 = Rich | first1 = A. | last2 = Toro | first2 = TZ. | last3 = Tanksley | first3 = J. | last4 = Fiske | first4 = WH. | last5 = Lind | first5 = CD. | last6 = Ayers | first6 = GD. | last7 = Piessevaux | first7 = H. | last8 = Washington | first8 = MK. | last9 = Coffey | first9 = RJ. | title = Distinguishing Ménétrier's disease from its mimics. | journal = Gut | volume = 59 | issue = 12 | pages = 1617-24 | month = Dec | year = 2010 | doi = 10.1136/gut.2010.220061 | PMID = 20926644 }}</ref> | ||
*Classic: nausea | *Classic: nausea and emesis (intractable). | ||
*Others: abdominal pain and peripheral edema. | |||
Other: | Other: | ||
*Gastric mass (may mimic cancer). | *Gastric mass (may mimic cancer). | ||
*Hypochlorhydria. | *Hypochlorhydria. | ||
*Protein loss - leads to peripheral edema. | *Protein loss (hypoalbuminemia) - leads to peripheral edema. | ||
Epidemiology: | |||
*Men > women. | |||
*Adults usually 50s. | |||
*Associated with [[ulcerative colitis]]. | |||
===Gross=== | |||
*"Bag of worms" appearance - very thick gastric folds. | |||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref> | Features:<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref> | ||
*Foveolar cell hyperplasia - '''key feature'''. | *Foveolar cell hyperplasia - '''key feature'''. | ||
*Decreased parietal cells. | |||
*+/-Inflammation. | |||
DDx: | DDx: | ||