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Difference between revisions of "Gallbladder"
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→Microscopic
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Features: | Features: | ||
*Gallbladder epithelium with: | *Gallbladder epithelium with: | ||
**Nuclear | **Nuclear atypia - '''key feature'''. | ||
**Nuclear hyperchromasia. | ***Nuclear hyperchromasia. | ||
***Nuclear crowding (pseudostratification) ''or'' round enlarged nuclei. | |||
**+/-Goblet cells. | **+/-Goblet cells. | ||
Architectural subclassification:<ref name=pmid22895264>{{Cite journal | last1 = Adsay | first1 = V. | last2 = Jang | first2 = KT. | last3 = Roa | first3 = JC. | last4 = Dursun | first4 = N. | last5 = Ohike | first5 = N. | last6 = Bagci | first6 = P. | last7 = Basturk | first7 = O. | last8 = Bandyopadhyay | first8 = S. | last9 = Cheng | first9 = JD. | title = Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases. | journal = Am J Surg Pathol | volume = 36 | issue = 9 | pages = 1279-301 | month = Sep | year = 2012 | doi = 10.1097/PAS.0b013e318262787c | PMID = 22895264 }}</ref> | |||
*Papillary ~ 45%. | *Papillary ~ 45%. | ||
*Tubulopapillary ~ 30%. | *Tubulopapillary ~ 30%. | ||
| Line 367: | Line 368: | ||
Notes: | Notes: | ||
*All of the gallbladder should be submitted prior to sign out to exclude non-sampled adenocarcinoma. | *All of the gallbladder should be submitted prior to sign out to exclude non-sampled adenocarcinoma. | ||
DDx: | DDx: | ||
*[[Gallbladder adenocarcinoma]]. | *[[Gallbladder adenocarcinoma]]. | ||
*Reactive changes. | |||
Image: | Image: | ||