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Difference between revisions of "Vulva"
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→Vulvar squamous cell carcinoma
m (→Microscopic) |
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==Vulvar squamous cell carcinoma== | ==Vulvar squamous cell carcinoma== | ||
{{Main|Squamous cell carcinoma}} | {{Main|Squamous cell carcinoma}} | ||
===General=== | |||
*Most common vulvar malignancy. | |||
* | |||
====Precursor lesions for SCC==== | |||
===Precursor lesions for SCC=== | |||
*Vulvar intraepithelial neoplasia (VIN). | *Vulvar intraepithelial neoplasia (VIN). | ||
| Line 27: | Line 21: | ||
Low grade pre-cancerous lesions (VIN) are typically [[HPV]] positive, while high grade pre-cancerous lesions and [[cancer]] are less often HPV positive.<ref name=pmid19115209>{{cite journal |author=De Vuyst H, Clifford GM, Nascimento MC, Madeleine MM, Franceschi S |title=Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis |journal=Int. J. Cancer |volume=124 |issue=7 |pages=1626–36 |year=2009 |month=April |pmid=19115209 |doi=10.1002/ijc.24116 |url=}}</ref> | Low grade pre-cancerous lesions (VIN) are typically [[HPV]] positive, while high grade pre-cancerous lesions and [[cancer]] are less often HPV positive.<ref name=pmid19115209>{{cite journal |author=De Vuyst H, Clifford GM, Nascimento MC, Madeleine MM, Franceschi S |title=Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis |journal=Int. J. Cancer |volume=124 |issue=7 |pages=1626–36 |year=2009 |month=April |pmid=19115209 |doi=10.1002/ijc.24116 |url=}}</ref> | ||
===Microscopic=== | |||
Like SCC elsewhere. | |||
*Microinvasion: <=1 mm stromal invasion, tumour size <=2 cm (T1a).<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Vulva_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Vulva_11protocol.pdf]. Accessed on: 9 March 2012.</ref> | |||
*Depth from DE junction. | |||
Note: | |||
*Tumour thickness != depth of invasion. | |||
**Thickness = granular layer ''or'' surface (no granular layer present) to deepest tumour. | |||
**Depth of invasion = epithelial-stromal junction in "valley" of papillae. | |||
==Classic vulvar intraepithelial neoplasia== | ==Classic vulvar intraepithelial neoplasia== | ||