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*Intraepidermal ascent of cells is usually suggestive of melanoma. | *Intraepidermal ascent of cells is usually suggestive of melanoma. | ||
**In acral sites the criteria are relaxed, i.e. this is considered benign for this site. | **In acral sites (esp. at the centre of a lesion) the criteria are relaxed, i.e. this is considered benign for this site. | ||
*Nests in the ridges raise the suspicion of melanoma. | *Nests in the ridges raise the suspicion of melanoma. | ||
**Memory device "ridges are risky, furrows are fine".<ref name=pmid22703907>{{Cite journal | last1 = Elston | first1 = D. | title = Practical advice regarding problematic pigmented lesions. | journal = J Am Acad Dermatol | volume = 67 | issue = 1 | pages = 148-55 | month = Jul | year = 2012 | doi = 10.1016/j.jaad.2012.04.006 | PMID = 22703907 }}</ref> | **Memory device "ridges are risky, furrows are fine".<ref name=pmid22703907>{{Cite journal | last1 = Elston | first1 = D. | title = Practical advice regarding problematic pigmented lesions. | journal = J Am Acad Dermatol | volume = 67 | issue = 1 | pages = 148-55 | month = Jul | year = 2012 | doi = 10.1016/j.jaad.2012.04.006 | PMID = 22703907 }}</ref> |
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