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Difference between revisions of "Dermatologic neoplasms"
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Dermatologic neoplasms (view source)
Revision as of 12:26, 24 December 2012
, 12:26, 24 December 2012→Sebaceous carcinoma: expand
(→Sebaceous carcinoma: expand) |
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*Malignant. | *Malignant. | ||
*May arise in a [[salivary gland]].<ref name=Warman/> | *May arise in a [[salivary gland]].<ref name=Warman/> | ||
*Can be part of [[Muir-Torre syndrome]]. | |||
Notes: | Notes: | ||
*Sebaceous lesions (from benign to malignant): [[sebaceous hyperplasia]], [[sebaceous adenoma]], sebaceoma, sebaceous carcinoma. | *Sebaceous lesions (from benign to malignant): [[sebaceous hyperplasia]], [[sebaceous adenoma]], sebaceoma, sebaceous carcinoma. | ||
===Gross=== | |||
Features:<ref name=Ref_Derm431>{{Ref Derm|431}}</ref> | |||
*Classically [[head and neck pathology|head and neck]] tumour. | |||
*Yellow or red (ulcerated) nodule. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref name=Ref_Derm431-2>{{Ref Derm|431-2}}</ref> | ||
*Sebaceous differentiation - may be a minor component - '''key feature'''. | |||
**Sebocytes = abundant pale fluffy cytoplasm with vacuolization. | |||
*Basaloid cells - often dominant. | |||
**May lead to confusion with basaloid tumours. | |||
*Nodular or diffuse growth pattern surrounded by a dense fibrous stroma. | |||
*Nuclear atypia. | *Nuclear atypia. | ||
* | *+/-Squamous differentiation. | ||
* | *+/-Foreign body-type [[giant cells]]. | ||
DDx: | DDx: | ||
*[[Squamous cell carcinoma]], clear cell variant. | |||
*[[Malignant melanoma]]. | |||
*[[Extramammary Paget disease]]. | |||
*[[Trichoblastoma]]. | *[[Trichoblastoma]]. | ||
*[[Basal cell carcinoma]]. | |||
*[[Sweat gland carcinoma]]. | |||
Images: | Images: | ||
| Line 511: | Line 527: | ||
**[http://commons.wikimedia.org/wiki/File:Sebaceous_carcinoma_-_intermed_mag.jpg Sebaceous carcinoma - intermed. mag. (WC)]. | **[http://commons.wikimedia.org/wiki/File:Sebaceous_carcinoma_-_intermed_mag.jpg Sebaceous carcinoma - intermed. mag. (WC)]. | ||
**[http://commons.wikimedia.org/wiki/File:Sebaceous_carcinoma_-_very_high_mag.jpg Sebaceous carcinoma - very high mag. (WC)]. | **[http://commons.wikimedia.org/wiki/File:Sebaceous_carcinoma_-_very_high_mag.jpg Sebaceous carcinoma - very high mag. (WC)]. | ||
====Grading=== | |||
Three tier system:<ref name=Ref_Derm431-2>{{Ref Derm|431-2}}</ref> | |||
*Well-differentiated. | |||
*Moderately differentiated. | |||
*Poorly differentiated. | |||
===IHC=== | ===IHC=== | ||
*CK7 +ve.<ref name=pmid21592202>{{Cite journal | last1 = Ansai | first1 = S. | last2 = Arase | first2 = S. | last3 = Kawana | first3 = S. | last4 = Kimura | first4 = T. | title = Immunohistochemical findings of sebaceous carcinoma and sebaceoma: retrieval of cytokeratin expression by a panel of anti-cytokeratin monoclonal antibodies. | journal = J Dermatol | volume = 38 | issue = 10 | pages = 951-8 | month = Oct | year = 2011 | doi = 10.1111/j.1346-8138.2011.01274.x | PMID = 21592202 }}</ref> | *CK7 +ve.<ref name=pmid21592202>{{Cite journal | last1 = Ansai | first1 = S. | last2 = Arase | first2 = S. | last3 = Kawana | first3 = S. | last4 = Kimura | first4 = T. | title = Immunohistochemical findings of sebaceous carcinoma and sebaceoma: retrieval of cytokeratin expression by a panel of anti-cytokeratin monoclonal antibodies. | journal = J Dermatol | volume = 38 | issue = 10 | pages = 951-8 | month = Oct | year = 2011 | doi = 10.1111/j.1346-8138.2011.01274.x | PMID = 21592202 }}</ref> | ||
*EMA +ve.<ref name=Ref_Derm431-2>{{Ref Derm|431-2}}</ref> | |||
*CEA -ve. | |||
**Positive in [[EMPD]]. | |||
==Microcystic adnexal carcinoma== | ==Microcystic adnexal carcinoma== | ||