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Difference between revisions of "Duodenum"
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==Whipple's disease== | ==Whipple's disease== | ||
===Epidemiology=== | ===General=== | ||
====Epidemiology==== | |||
*Very rare. | *Very rare. | ||
*Classically middle aged men. | *Classically middle aged men. | ||
===Clinical=== | ====Clinical==== | ||
*Malabsorption (diarrhea), arthritis + others. | *Malabsorption (diarrhea), arthritis + others. | ||
**Symptoms are non-specific. | **Symptoms are non-specific. | ||
===Etiology=== | Treatment: | ||
*Antibiotics - for months and months. | |||
====Etiology==== | |||
*Infection - caused by ''Tropheryma whipplei''.<ref>{{cite journal |author=Liang Z, La Scola B, Raoult D |title=Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei |journal=Clin. Diagn. Lab. Immunol. |volume=9 |issue=1 |pages=156?9 |year=2002 |month=January |pmid=11777846 |pmc=119894 |doi= |url=http://cvi.asm.org/cgi/pmidlookup?view=long&pmid=11777846}}</ref> | *Infection - caused by ''Tropheryma whipplei''.<ref>{{cite journal |author=Liang Z, La Scola B, Raoult D |title=Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei |journal=Clin. Diagn. Lab. Immunol. |volume=9 |issue=1 |pages=156?9 |year=2002 |month=January |pmid=11777846 |pmc=119894 |doi= |url=http://cvi.asm.org/cgi/pmidlookup?view=long&pmid=11777846}}</ref> | ||
=== | ===Microscopic=== | ||
Features:<ref>{{cite journal | author=Bai J, Mazure R, Vazquez H, Niveloni S, Smecuol E, Pedreira S, Mauriño E | title=Whipple's disease | journal=Clin Gastroenterol Hepatol | volume=2 | issue=10 | pages=849?60 | year=2004 | pmid=15476147 | doi=10.1016/S1542-3565(04)00387-8}}</ref> | Features:<ref>{{cite journal | author=Bai J, Mazure R, Vazquez H, Niveloni S, Smecuol E, Pedreira S, Mauriño E | title=Whipple's disease | journal=Clin Gastroenterol Hepatol | volume=2 | issue=10 | pages=849?60 | year=2004 | pmid=15476147 | doi=10.1016/S1542-3565(04)00387-8}}</ref> | ||
*Infectious microorganism typically found in macrophages. | *Infectious microorganism typically found in macrophages. | ||
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**Organisms periodic acid-Schiff (PAS) positive. | **Organisms periodic acid-Schiff (PAS) positive. | ||
Micrograph: [http://en.wikipedia.org/wiki/File:Whipple2.jpg Whipple's disease] - wikipedia.org. | |||
DDx: | |||
*Mycobacterium avium intracellulare (MAI). | |||
==Tumours== | ==Tumours== | ||