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Difference between revisions of "Gastrointestinal tract polyps"
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Gastrointestinal tract polyps (view source)
Revision as of 23:51, 20 November 2012
, 23:51, 20 November 2012→Malignant polyps: tweak
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Features:<ref name=pmid22827760>{{Cite journal | last1 = Kimura | first1 = R. | last2 = Fujimori | first2 = T. | last3 = Ichikawa | first3 = K. | last4 = Ajioka | first4 = Y. | last5 = Ueno | first5 = H. | last6 = Ohkura | first6 = Y. | last7 = Kashida | first7 = H. | last8 = Togashi | first8 = K. | last9 = Yao | first9 = T. | title = Desmoplastic reaction in biopsy specimens of early colorectal cancer: a Japanese prospective multicenter study. | journal = Pathol Int | volume = 62 | issue = 8 | pages = 525-31 | month = Aug | year = 2012 | doi = 10.1111/j.1440-1827.2012.02840.x | PMID = 22827760 }}</ref> | Features:<ref name=pmid22827760>{{Cite journal | last1 = Kimura | first1 = R. | last2 = Fujimori | first2 = T. | last3 = Ichikawa | first3 = K. | last4 = Ajioka | first4 = Y. | last5 = Ueno | first5 = H. | last6 = Ohkura | first6 = Y. | last7 = Kashida | first7 = H. | last8 = Togashi | first8 = K. | last9 = Yao | first9 = T. | title = Desmoplastic reaction in biopsy specimens of early colorectal cancer: a Japanese prospective multicenter study. | journal = Pathol Int | volume = 62 | issue = 8 | pages = 525-31 | month = Aug | year = 2012 | doi = 10.1111/j.1440-1827.2012.02840.x | PMID = 22827760 }}</ref> | ||
*Desmoplastic response - '''key feature'''. | *Desmoplastic response - '''key feature'''. | ||
**Spindle cells with large nuclei. | |||
***Nuclei ~ size of a plasma cell. | |||
**Eosinophilic cytoplasm. | |||
*Nuclear changes seen in adenomatous polyps. | *Nuclear changes seen in adenomatous polyps. | ||
**Enlarged. | **Enlarged. | ||
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*Desmoplastic response is ''not'' predictive of submucosal invasion in pedunculated polyps.<ref name=pmid20665053>{{Cite journal | last1 = Hirose | first1 = M. | last2 = Fukui | first2 = H. | last3 = Igarashi | first3 = Y. | last4 = Fujimori | first4 = Y. | last5 = Katake | first5 = Y. | last6 = Sekikawa | first6 = A. | last7 = Ichikawa | first7 = K. | last8 = Tomita | first8 = S. | last9 = Imura | first9 = J. | title = Detection of desmoplastic reaction in biopsy specimens is useful for predicting the depth of invasion of early colorectal cancer: a Japanese collaborative study. | journal = J Gastroenterol | volume = 45 | issue = 12 | pages = 1212-8 | month = Dec | year = 2010 | doi = 10.1007/s00535-010-0288-3 | PMID = 20665053 }} | *Desmoplastic response is ''not'' predictive of submucosal invasion in pedunculated polyps.<ref name=pmid20665053>{{Cite journal | last1 = Hirose | first1 = M. | last2 = Fukui | first2 = H. | last3 = Igarashi | first3 = Y. | last4 = Fujimori | first4 = Y. | last5 = Katake | first5 = Y. | last6 = Sekikawa | first6 = A. | last7 = Ichikawa | first7 = K. | last8 = Tomita | first8 = S. | last9 = Imura | first9 = J. | title = Detection of desmoplastic reaction in biopsy specimens is useful for predicting the depth of invasion of early colorectal cancer: a Japanese collaborative study. | journal = J Gastroenterol | volume = 45 | issue = 12 | pages = 1212-8 | month = Dec | year = 2010 | doi = 10.1007/s00535-010-0288-3 | PMID = 20665053 }} | ||
</ref> | </ref> | ||
===Sign out=== | |||
<pre> | |||
RECTOSIGMOID TUMOUR, BIOPSY: | |||
- INVASIVE ADENOCARCINOMA, MODERATELY DIFFERENTIATED. | |||
</pre> | |||
====Micro==== | |||
The sections shows colorectal-type mucosa with a tubule-forming epithelium that has cellular pseudostratification and enlarged hyperchromatic nuclei, from the crypt base to the luminal aspect (dysplasia). | |||
There is cribriforming of glands and epithelial budding. Plump spindle cells with pale eosinophilic cytoplasm surround the abnormal epithelium (desmoplastic stroma). No definite submucosa is identified; diagnosis based on stromal desmoplasia. | |||
=Hamartomatous polyps= | =Hamartomatous polyps= | ||