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Difference between revisions of "Celiac sprue"
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→Microscopic: update
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=Ref_PBoD843>{{Ref PBoD|843}}</ref> | Features:<ref name=Ref_PBoD843>{{Ref PBoD|843}}</ref> | ||
*Intraepithelial lymphocytes - '''key feature'''. | |||
**Should be more pronounced at tips of villi.<ref name=pmid15280404>{{cite journal |author=Biagi F, Luinetti O, Campanella J, ''et al.'' |title=Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease? |journal=J. Clin. Pathol. |volume=57 |issue=8 |pages=835–9 |year=2004 |month=August |pmid=15280404 |pmc=1770380 |doi=10.1136/jcp.2003.013607 |url=}}</ref> | |||
** | |||
*Loss of villi - '''important feature'''. | *Loss of villi - '''important feature'''. | ||
**Normal duodenal biopsy should have 3 good villi. | **Normal duodenal biopsy should have 3 good villi. | ||
*Plasma cells - abundant (weak feature). | |||
*Macrophages. | |||
*Mitosis increased (in the crypts). | *Mitosis increased (in the crypts). | ||
*+/-Collagen band (pink material in mucosa) - "Collagenous sprue"; must encompass ~25% of mucosa. | *+/-Collagen band (pink material in mucosa) - "Collagenous sprue"; must encompass ~25% of mucosa. | ||