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Difference between revisions of "Endometrium"
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→Atrophic endometrium: tweak
(→Tamoxifen effects: w) |
(→Atrophic endometrium: tweak) |
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*Very common diagnosis. | *Very common diagnosis. | ||
**Atrophy may be associated with bleeding and therefore biopsied to rule-out hyperplasia and malignancy. | **Atrophy may be associated with bleeding and therefore biopsied to rule-out hyperplasia and malignancy. | ||
===Gross=== | |||
*Thin endometrium. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Glands: | *Glands - small columnar cells: | ||
** | **Moderate quantity of eosinophilic cytoplasm. | ||
**+/- | **Ovoid (palisaded) nuclei +/- nuclear pseudostratification.<ref name=pmid16873562>{{Cite journal | last1 = McCluggage | first1 = WG. | title = My approach to the interpretation of endometrial biopsies and curettings. | journal = J Clin Pathol | volume = 59 | issue = 8 | pages = 801-12 | month = Aug | year = 2006 | doi = 10.1136/jcp.2005.029702 | PMID = 16873562 | PMC = 1860448 }}</ref> | ||
** | **Eosinophilic cytoplasm. | ||
* | **No mitoses. | ||
*Architecture: | |||
**+/-Cystic dilation. | |||
Notes: | Notes: | ||
*If a woman is truly postmenopausal, mitoses in the glandular epithelium is pathologic until demonstrated otherwise. | *If a woman is truly postmenopausal, mitoses in the glandular epithelium is pathologic until demonstrated otherwise. | ||
**The | **The exceptions are [[benign endometrial polyp]], [[uterine prolapse]], and possibly inflammation (e.g. the person has had several biopsy attempts and was seeded with pathogens). | ||
DDx: | DDx: | ||
*[[Proliferative phase endometrium]] - esp. if there is pseudostratification. | *[[Proliferative phase endometrium]] - esp. if there is pseudostratification. | ||
*[[Serous carcinoma of the endometrium]]. | *[[Serous carcinoma of the endometrium]]. | ||
Images: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860448/figure/fig1/ Atrophic endometrium (nih.gov)].<ref name=pmid16873562/> | |||
==Endometrial hyperplasia== | ==Endometrial hyperplasia== | ||