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Difference between revisions of "Ovarian tumours"
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→Clear cell carcinoma of the ovary: +DDx
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===General=== | ===General=== | ||
* Thought to be related to endometrioid carcinoma.<ref name=Ref_PBoD1098>{{Ref PBoD |1098}}</ref> | * Thought to be related to endometrioid carcinoma.<ref name=Ref_PBoD1098>{{Ref PBoD |1098}}</ref> | ||
* Worse prognosis versus other surface epithelial tumours.<ref name=pmid18035678>{{cite journal |author=Hauptmann S, Köbel M |title=[Prognostic factors in ovarian carcinoma] |language=German |journal=Verh Dtsch Ges Pathol |volume=89 |issue= |pages=92-100 |year=2005 |pmid=18035678 |doi= |url=}}</ref> | |||
* Worse prognosis | * Asians appear to be at an increased risk.<ref name=pmid22885379>{{Cite journal | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref> | ||
Association with endometriosis:<ref name=pmid22885379/> | |||
* Increased risk of ovarian clear cell carcinoma ~ 3x. | |||
* Seen in 50-70% of ovarian CCC. | |||
===Microscopic=== | ===Microscopic=== | ||
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*Cystic/tubular architecture - important low power feature. | *Cystic/tubular architecture - important low power feature. | ||
*Clear cells - cytoplasm is clear - '''key feature'''. | *Clear cells - cytoplasm is clear - '''key feature'''. | ||
*[[Hobnail morphology]] - apical surface larger than basal surface. | *[[Hobnail morphology]] - apical surface larger than basal surface. | ||
**"Nuclei bulge into the lumen". | **"Nuclei bulge into the lumen". | ||
*Hyaline droplets -- common, as in ''[[clear cell renal cell carcinoma]]''. | *Hyaline droplets -- common, as in ''[[clear cell renal cell carcinoma]]''. | ||
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*Clear cell adenocarcinoma does not have to have clear cells. Yes, this is stupid; it is like ''[[papillary thyroid carcinoma]]'' -- which often isn't papillary -- see ''[[no truth in names]]''. | *Clear cell adenocarcinoma does not have to have clear cells. Yes, this is stupid; it is like ''[[papillary thyroid carcinoma]]'' -- which often isn't papillary -- see ''[[no truth in names]]''. | ||
**The ''hobnail morphology'' is important if this is the case. | **The ''hobnail morphology'' is important if this is the case. | ||
DDx: | |||
*[[Serous carcinoma of the ovary]]. | |||
*High-grade [[endometrioid carcinoma of the ovary]]. | |||
*[[Metastasis|Metatstatic]] [[clear cell carcinoma]]. | |||
Images: | Images: | ||