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Difference between revisions of "Dermatopathology"
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→Layers of the skin
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*Subdermis - below the dermis, connective tissue. | *Subdermis - below the dermis, connective tissue. | ||
===Layers of the epidermis=== | ===Epidermis=== | ||
====Layers of the epidermis==== | |||
Epidermis layers - from the surface to epidermal-dermal junction: | Epidermis layers - from the surface to epidermal-dermal junction: | ||
*Stratum corneum. | *Stratum corneum. | ||
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====Cells of the epidermis==== | ====Cells of the epidermis==== | ||
*Keratinocytes. | *Keratinocytes. | ||
** | **Usually eosinophilic cytoplasm - '''important feature'''. | ||
**May have clear perinuclear halo (glycogenated keratinocytes). | **May have clear perinuclear halo (glycogenated keratinocytes). | ||
**Intercellular bridges (high power) - '''key feature'''. | **Intercellular bridges (high power) - '''key feature'''. | ||
*Melanocytes. | *Melanocytes. | ||
** | **Usuallly basal location. | ||
**Epithelioid or dentritic morphology. | **Epithelioid or dentritic morphology. | ||
**Pericellular clearing - '''key feature'''. | **Pericellular clearing - '''key feature'''. | ||
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***[[Paget disease]]: large cells with clear cytoplasm, may cluster, above basal layer. | ***[[Paget disease]]: large cells with clear cytoplasm, may cluster, above basal layer. | ||
=== | ====Normal histology==== | ||
Subdivided into: | Features: | ||
*Keratinocytes: | |||
**Basal ~ 2x [[RBC]]. | |||
***May palisade focally ~ 1:2 = width: height. | |||
===Dermis=== | |||
Subdivided into layers: | |||
#Papillary dermis. | #Papillary dermis. | ||
#*Location: superficial - opposed to the deep aspect of the epidermis. | #*Location: superficial - opposed to the deep aspect of the epidermis. | ||