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Difference between revisions of "Prostate cancer"
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→Unusual forms of prostate cancer: +intraductal
(+unusual forms) |
(→Unusual forms of prostate cancer: +intraductal) |
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- ADDITIONAL FINDINGS: HIGH-GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA, CHRONIC INFLAMMATION (FOCAL). | - ADDITIONAL FINDINGS: HIGH-GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA, CHRONIC INFLAMMATION (FOCAL). | ||
</pre> | </pre> | ||
=Intraductal spread of prostate cancer= | |||
==Intraductal carcinoma of the prostate== | |||
*[[AKA]] ''intraductal carcinoma''. | |||
*[[AKA]] ''intraductal prostate carcinoma''. | |||
===General=== | |||
*Associated with a poor prognosis.<ref name=pmid19246509>{{Cite journal | last1 = Henry | first1 = PC. | last2 = Evans | first2 = AJ. | title = Intraductal carcinoma of the prostate: a distinct histopathological entity with important prognostic implications. | journal = J Clin Pathol | volume = 62 | issue = 7 | pages = 579-83 | month = Jul | year = 2009 | doi = 10.1136/jcp.2009.065003 | PMID = 19246509 }}</ref> | |||
*Strong association with aggressive invasive carcinomas on prostatectomy when identified in isolation on biopsy.<ref name=pmid20723921>{{Cite journal | last1 = Robinson | first1 = BD. | last2 = Epstein | first2 = JI. | title = Intraductal carcinoma of the prostate without invasive carcinoma on needle biopsy: emphasis on radical prostatectomy findings. | journal = J Urol | volume = 184 | issue = 4 | pages = 1328-33 | month = Oct | year = 2010 | doi = 10.1016/j.juro.2010.06.017 | PMID = 20723921 }}</ref> | |||
===Microscopic=== | |||
Features: | |||
*Malignant cells in glands with basal cells - '''key feature'''. | |||
**Two cell populations: | |||
**#Obviously malignant cells with enlarged nuclei, granular chromatin, hyperchromasia and nucleoli. | |||
**#Cells with pale cytoplasm and smaller nuclei. | |||
DDx: | |||
*[[HGPIN]]. | |||
===IHC=== | |||
Features - basal cells present: | |||
*HMWK +ve. | |||
=Unusual forms of prostate cancer= | =Unusual forms of prostate cancer= | ||