Difference between revisions of "Prostate gland"

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Prostate gland (view source)

Revision as of 16:53, 15 October 2012

1,299 bytes removed ,  16:53, 15 October 2012
mv intraductal
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*[[Prostatic adenocarcinoma]].
*[[Prostatic adenocarcinoma]].


==Intraductal carcinoma of the prostate==
=Prostate cancer=
*[[AKA]] ''intraductal carcinoma''.
{{Main|Prostate cancer}}
*[[AKA]] ''intraductal prostate carcinoma''.
This is a big topic that is dealt with in its own article.
===General===
*Associated with a poor prognosis.<ref name=pmid19246509>{{Cite journal  | last1 = Henry | first1 = PC. | last2 = Evans | first2 = AJ. | title = Intraductal carcinoma of the prostate: a distinct histopathological entity with important prognostic implications. | journal = J Clin Pathol | volume = 62 | issue = 7 | pages = 579-83 | month = Jul | year = 2009 | doi = 10.1136/jcp.2009.065003 | PMID = 19246509 }}</ref>
*Strong association with aggressive invasive carcinomas on prostatectomy when identified in isolation on biopsy.<ref name=pmid20723921>{{Cite journal  | last1 = Robinson | first1 = BD. | last2 = Epstein | first2 = JI. | title = Intraductal carcinoma of the prostate without invasive carcinoma on needle biopsy: emphasis on radical prostatectomy findings. | journal = J Urol | volume = 184 | issue = 4 | pages = 1328-33 | month = Oct | year = 2010 | doi = 10.1016/j.juro.2010.06.017 | PMID = 20723921 }}</ref>
 
===Microscopic===
Features:
*Malignant cells in glands with basal cells - '''key feature'''.
**Two cell populations:
**#Obviously malignant cells with enlarged nuclei, granular chromatin, hyperchromasia and nucleoli.
**#Cells with pale cytoplasm and smaller nuclei.
 
DDx:
*[[HGPIN]].
 
===IHC===
Features - basal cells present:
*HMWK +ve.


=See also=
=See also=
Michael
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