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Difference between revisions of "Leiomyosarcoma"
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→Microscopic
m (→IHC) |
m (→Microscopic) |
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
* | *Usually a cellular lesion. | ||
*Fasciclar arrangement: | *Fasciclar arrangement: | ||
**Whorled look at low power. | **Whorled look at low power. | ||
| Line 29: | Line 29: | ||
*#*>=2 mitoses/HPF - if [[myxoid]].<ref name=Ref_GP281>{{Ref GP|281}}</ref> | *#*>=2 mitoses/HPF - if [[myxoid]].<ref name=Ref_GP281>{{Ref GP|281}}</ref> | ||
*#*>=1 mitosis/HPF - if cutaneous.<ref name=pmid21358302>{{cite journal |author=Kraft S, Fletcher CD |title=Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous "leiomyosarcoma" |journal=Am. J. Surg. Pathol. |volume=35 |issue=4 |pages=599–607 |year=2011 |month=April |pmid=21358302 |doi=10.1097/PAS.0b013e31820e6093 |url=}}</ref> | *#*>=1 mitosis/HPF - if cutaneous.<ref name=pmid21358302>{{cite journal |author=Kraft S, Fletcher CD |title=Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous "leiomyosarcoma" |journal=Am. J. Surg. Pathol. |volume=35 |issue=4 |pages=599–607 |year=2011 |month=April |pmid=21358302 |doi=10.1097/PAS.0b013e31820e6093 |url=}}</ref> | ||
*+/-Heterologous elements, e.g. malignant cartilage or bone.<ref name=pmid22833086>{{Cite journal | last1 = Anh Tran | first1 = T. | last2 = Holloway | first2 = RW. | title = Metastatic leiomyosarcoma of the uterus with heterologous differentiation to malignant mesenchymoma. | journal = Int J Gynecol Pathol | volume = 31 | issue = 5 | pages = 453-7 | month = Sep | year = 2012 | doi = 10.1097/PGP.0b013e318246977d | PMID = 22833086 }}</ref> | |||
Notes: | |||
*Leiomyosarcoma ''de facto'' trumps other sarcomas.<ref name=pmid22833086/> | |||
Images: | Images: | ||