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Difference between revisions of "P63"
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'''p63''' is a commonly used [[immunostain]]. | '''p63''' is a commonly used [[immunostain]]. p63, like most other "p" stains, is a nuclear stain. | ||
==Pattern== | |||
*Nuclear staining. | |||
Note: | |||
*Cytoplasmic staining suggestive of muscle differentiation - seen in [[rhabdomyosarcoma]].<ref name=pmid21623385>{{Cite journal | last1 = Martin | first1 = SE. | last2 = Temm | first2 = CJ. | last3 = Goheen | first3 = MP. | last4 = Ulbright | first4 = TM. | last5 = Hattab | first5 = EM. | title = Cytoplasmic p63 immunohistochemistry is a useful marker for muscle differentiation: an immunohistochemical and immunoelectron microscopic study. | journal = Mod Pathol | volume = 24 | issue = 10 | pages = 1320-6 | month = Oct | year = 2011 | doi = 10.1038/modpathol.2011.89 | PMID = 21623385 }}</ref> | |||
==Classic use== | ==Classic use== | ||
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==Non-classic tumours== | ==Non-classic tumours== | ||
*Di Como ''et al''<ref name=pmid11839669>{{Cite journal | last1 = Di Como | first1 = CJ. | last2 = Urist | first2 = MJ. | last3 = Babayan | first3 = I. | last4 = Drobnjak | first4 = M. | last5 = Hedvat | first5 = CV. | last6 = Teruya-Feldstein | first6 = J. | last7 = Pohar | first7 = K. | last8 = Hoos | first8 = A. | last9 = Cordon-Cardo | first9 = C. | title = p63 expression profiles in human normal and tumor tissues. | journal = Clin Cancer Res | volume = 8 | issue = 2 | pages = 494-501 | month = Feb | year = 2002 | doi = | PMID = 11839669 }}</ref> looked at a large cross-section of | *Di Como ''et al''<ref name=pmid11839669>{{Cite journal | last1 = Di Como | first1 = CJ. | last2 = Urist | first2 = MJ. | last3 = Babayan | first3 = I. | last4 = Drobnjak | first4 = M. | last5 = Hedvat | first5 = CV. | last6 = Teruya-Feldstein | first6 = J. | last7 = Pohar | first7 = K. | last8 = Hoos | first8 = A. | last9 = Cordon-Cardo | first9 = C. | title = p63 expression profiles in human normal and tumor tissues. | journal = Clin Cancer Res | volume = 8 | issue = 2 | pages = 494-501 | month = Feb | year = 2002 | doi = | PMID = 11839669 }}</ref> looked at a large cross-section of tumours. | ||
*Jo and Fletcher<ref name=pmid22031315>{{Cite journal | last1 = Jo | first1 = VY. | last2 = Fletcher | first2 = CD. | title = p63 immunohistochemical staining is limited in soft tissue tumors. | journal = Am J Clin Pathol | volume = 136 | issue = 5 | pages = 762-6 | month = Nov | year = 2011 | doi = 10.1309/AJCPXNUC7JZSKWEU | PMID = 22031315 }}</ref> did a paper on [[soft tissue lesions]] and p63. | *Jo and Fletcher<ref name=pmid22031315>{{Cite journal | last1 = Jo | first1 = VY. | last2 = Fletcher | first2 = CD. | title = p63 immunohistochemical staining is limited in soft tissue tumors. | journal = Am J Clin Pathol | volume = 136 | issue = 5 | pages = 762-6 | month = Nov | year = 2011 | doi = 10.1309/AJCPXNUC7JZSKWEU | PMID = 22031315 }}</ref> did a paper on [[soft tissue lesions]] and p63. | ||