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Difference between revisions of "Stomach"
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→Neoplastic: +gastric neuroendocrine tumour
(→Neoplastic: +gastric neuroendocrine tumour) |
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*[http://commons.wikimedia.org/w/index.php?title=File:High_grade_gastric_dysplasia_-_very_high_mag.jpg High grade gastric dysplasia - very high mag. (WC)]. | *[http://commons.wikimedia.org/w/index.php?title=File:High_grade_gastric_dysplasia_-_very_high_mag.jpg High grade gastric dysplasia - very high mag. (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Gastric_adenoma_(2).jpg Gastric adenoma (WC)]. | *[http://commons.wikimedia.org/wiki/File:Gastric_adenoma_(2).jpg Gastric adenoma (WC)]. | ||
==Gastric neuroendocrine tumour== | |||
===Overview=== | |||
Divided into four types:<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/StomachNET_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/StomachNET_11protocol.pdf]. Accessed on: 29 March 2012.</ref> | |||
{| class="wikitable sortable" | |||
!Tumour type | |||
!Relative prevalence | |||
!Multifocality | |||
!Tumour size | |||
!Typical location | |||
!Clinical | |||
!Other | |||
!Histology | |||
|- | |||
|Type 1 | |||
| ~75% | |||
| yes | |||
| small (5-10 mm) | |||
| body | |||
| benign typically, female:male ~ 4:1, 50-60 years | |||
| chronic atrophic gastritis - usu. autoimmune | |||
| WDNET, WDNEC | |||
|- | |||
|Type 2 | |||
| rare | |||
| yes | |||
| small ~15 mm | |||
| body | |||
| aggressive, ~50 years old | |||
| assoc. [[MEN I]], hyperchlorhydia | |||
| WDNEC, WDNET | |||
|- | |||
|Type 3 | |||
| 10-15% | |||
| no | |||
| small and large | |||
| variable location | |||
| aggressive if >2.0 cm, males > females | |||
| normal gastrin levels | |||
| WDNET | |||
|- | |||
|Type 4 | |||
| extremely rare | |||
| no | |||
| large | |||
| variable location | |||
| aggressive (mets usu. at time of Dx), males > females | |||
| elevated gastrin d/t parietal cell dysfunction | |||
| PDNEC | |||
|- | |||
|} | |||
Notes: | |||
*WDNET = well-differentiated neuroendocrine tumour. | |||
*WDNEC = well-differentiated neuroendocrine carcinoma. | |||
*PDNEC = poorly-differentiated neuroendocrine carinoma. | |||
===Microscopic=== | |||
:See [[neuroendocrine tumours]] | |||
=Neoplastic rare= | =Neoplastic rare= | ||