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Difference between revisions of "Malignant melanoma"
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nl update 24
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*Ulceration. | *Ulceration. | ||
*Regression - >75% of tumour. | *Regression - >75% of tumour. | ||
*Microsatellitosis - nest of tumour cells > 0.05 mm size, separated from primary tumour >=0.3 mm and <= 2 cm. | *Microsatellitosis - nest of tumour cells > 0.05 mm size, separated from primary tumour >=0.3 mm and <= 2 cm. | ||
*In transist metastasis. | *In transist metastasis. | ||
*[[Lymphovascular invasion]]. | *[[Lymphovascular invasion]]. | ||
*Perineural invasion. | *[[Perineural invasion]]. | ||
*Lack of tumour infiltrating lymphocytes (TILs).{{fact}} | |||
===Clinical=== | ===Clinical=== | ||
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====DDx==== | ====DDx==== | ||
*Carcinoma. | *Carcinoma. | ||
**Serous carcinoma - both serous carcinoma and melanoma have a large [[nucleolus]]. | **[[Serous carcinoma]] - both serous carcinoma and melanoma have a large [[nucleolus]]. | ||
*Sarcoma - as may have spindle cells. | *Sarcoma - as may have spindle cells. | ||
**[[Clear cell sarcoma]]. | **[[Clear cell sarcoma]] ([[AKA]] melanoma of the soft parts). | ||
**Metaplastic carcinoma. | **Metaplastic carcinoma. | ||
**Epithelioid [[angiosarcoma]]. | **Epithelioid [[angiosarcoma]]. | ||
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==[[Electron microscopy]]== | ==[[Electron microscopy]]== | ||
*Melanosomes. | *[[Melanosomes]]. | ||
Image(s): | Image(s): | ||
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==Stains== | ==Stains== | ||
*''Fontana-Masson stain'', stains melanin.<ref>URL: [http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm]. Accessed on: 5 May 2010.</ref> | *''[[Fontana-Masson stain]]'', stains melanin.<ref>URL: [http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm]. Accessed on: 5 May 2010.</ref> | ||
**May be useful to differentiate melanin from other brown stuff (e.g. lipofuscin, hemosiderin). | **May be useful to differentiate melanin from other brown stuff (e.g. lipofuscin, hemosiderin). | ||