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Difference between revisions of "Thyroid gland"
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nl update 23/24
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======Microscopic====== | ======Microscopic====== | ||
Features:<ref name=pmid19373912>{{cite journal |author=Urano M, Kiriyama Y, Takakuwa Y, Kuroda M |title=Tall cell variant of papillary thyroid carcinoma: Its characteristic features demonstrated by fine-needle aspiration cytology and immunohistochemical study |journal=Diagn. Cytopathol. |volume= |issue= |pages= |year=2009 |month=April |pmid=19373912 |doi=10.1002/dc.21086 |url=}}</ref> | Features:<ref name=pmid19373912>{{cite journal |author=Urano M, Kiriyama Y, Takakuwa Y, Kuroda M |title=Tall cell variant of papillary thyroid carcinoma: Its characteristic features demonstrated by fine-needle aspiration cytology and immunohistochemical study |journal=Diagn. Cytopathol. |volume= |issue= |pages= |year=2009 |month=April |pmid=19373912 |doi=10.1002/dc.21086 |url=}}</ref> | ||
*50% of cells with height 2x the width. | *50% of cells with height 2x the width.<ref name=pmid18925842>{{cite journal |author=Ghossein R, Livolsi VA |title=Papillary thyroid carcinoma tall cell variant |journal=Thyroid |volume=18 |issue=11 |pages=1179–81 |year=2008 |month=November |pmid=18925842 |doi=10.1089/thy.2008.0164 |url=}}</ref> | ||
**There is some disagreement on these criteria;<ref name=pmid18925842/> | **There is some disagreement on these criteria;<ref name=pmid18925842/> Raphael believes the height ought to be ~3x width, for 50% of the cells.<ref>S. Raphael. 17 January 2011.</ref> | ||
*Eosinophilic cytoplasm. | *Eosinophilic cytoplasm. | ||
*Well-defined cell borders. | *Well-defined cell borders. | ||
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Negative: | Negative: | ||
*Nuclei ''not'' pseudostratified, if pseudostratified consider ''columnar cell variant''. | *Nuclei ''not'' pseudostratified, if pseudostratified consider ''columnar cell variant''. | ||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Papillary_thyroid_carcinoma_tall_cell_var_intermed_mag.jpg PTC tall cell variant - intermed. mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Papillary_thyroid_carcinoma_tall_cell_var_high_mag.jpg PTC tall cell variant - high mag. (WC)]. | |||
=====Papillary thyroid carcinoma columnar cell variant===== | =====Papillary thyroid carcinoma columnar cell variant===== | ||
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DDx:<ref>Endo. fellow. 17 September 2009.</ref> | DDx:<ref>Endo. fellow. 17 September 2009.</ref> | ||
*Medullary thyroid carcinoma. | *[[Medullary thyroid carcinoma]]. | ||
*Poorly differentiated thyroid carcinoma. | *Poorly differentiated thyroid carcinoma. | ||