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Difference between revisions of "Vulva"
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→Malignant neoplasms overview: +IHC sections
(→Differentiated vulvar intraepithelial neoplasia: +image links) |
(→Malignant neoplasms overview: +IHC sections) |
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*[http://commons.wikimedia.org/wiki/File:Vulvar_intraepithelial_neoplasia3_2.jpg VIN III (WC)]. | *[http://commons.wikimedia.org/wiki/File:Vulvar_intraepithelial_neoplasia3_2.jpg VIN III (WC)]. | ||
*[http://www.brown.edu/Courses/Digital_Path/systemic_path/female/warty_VIN.html VIN (brown.edu)]. | *[http://www.brown.edu/Courses/Digital_Path/systemic_path/female/warty_VIN.html VIN (brown.edu)]. | ||
===IHC=== | |||
*Classic VIN: p16 +ve, p53 -ve. | |||
*Differentiated VIN: p16 -ve, p53 +ve.<ref name=pmid20062014>{{Cite journal | last1 = Pinto | first1 = AP. | last2 = Miron | first2 = A. | last3 = Yassin | first3 = Y. | last4 = Monte | first4 = N. | last5 = Woo | first5 = TY. | last6 = Mehra | first6 = KK. | last7 = Medeiros | first7 = F. | last8 = Crum | first8 = CP. | title = Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma. | journal = Mod Pathol | volume = 23 | issue = 3 | pages = 404-12 | month = Mar | year = 2010 | doi = 10.1038/modpathol.2009.179 | PMID = 20062014 }}</ref> | |||
Note: | |||
*p16 can be thought of as a poor man's HPV test. | |||
==Differentiated vulvar intraepithelial neoplasia== | ==Differentiated vulvar intraepithelial neoplasia== | ||
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**[http://commons.wikimedia.org/wiki/File:Differentiated_vulvar_intraepithelial_neoplasia_-_deep_-_high_mag.jpg Differentiated VIN - deep - high mag. (WC)]. | **[http://commons.wikimedia.org/wiki/File:Differentiated_vulvar_intraepithelial_neoplasia_-_deep_-_high_mag.jpg Differentiated VIN - deep - high mag. (WC)]. | ||
==IHC | ===IHC=== | ||
* | *Differentiated VIN: p16 -ve, p53 +ve.<ref name=pmid20062014/> | ||
* | *Classic VIN: p16 +ve, p53 -ve. | ||
Note: | |||
*p16 can be thought of as a poor man's [[HPV]] test. | |||
=Neoplasms (non-malignant)= | =Neoplasms (non-malignant)= | ||