Difference between revisions of "Vulva"

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==Classic vulvar intraepithelial neoplasia==
==Classic vulvar intraepithelial neoplasia==
===Epidemiology===
*Abbreviated ''classic VIN''.
*Classic VIN, like CIN, is associated with [[HPV]] and seen in younger women.


===General===
===General===
*Classic VIN is graded like cervical pre-cancerous lesions:
Epidemiology:
**VIN I.
*Classic VIN, like CIN, is associated with [[HPV]] and seen in younger women.
***DDx: [[condyloma acuminatum]].<ref name=pmid15870532>{{Cite journal  | last1 = Rufforny | first1 = I. | last2 = Wilkinson | first2 = EJ. | last3 = Liu | first3 = C. | last4 = Zhu | first4 = H. | last5 = Buteral | first5 = M. | last6 = Massoll | first6 = NA. | title = Human papillomavirus infection and p16(INK4a) protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma. | journal = J Low Genit Tract Dis | volume = 9 | issue = 2 | pages = 108-13 | month = Apr | year = 2005 | doi =  | PMID = 15870532 }}</ref>
***Uncommon.
**VIN II.
***Not common.
**VIN III.
***Commonly seen.


DDx:
Classic VIN is graded like cervical pre-cancerous lesions:
*Condyloma (genital wart).
*VIN I.
**Most caused by HPV.
**DDx: [[condyloma acuminatum]].<ref name=pmid15870532>{{Cite journal  | last1 = Rufforny | first1 = I. | last2 = Wilkinson | first2 = EJ. | last3 = Liu | first3 = C. | last4 = Zhu | first4 = H. | last5 = Buteral | first5 = M. | last6 = Massoll | first6 = NA. | title = Human papillomavirus infection and p16(INK4a) protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma. | journal = J Low Genit Tract Dis | volume = 9 | issue = 2 | pages = 108-13 | month = Apr | year = 2005 | doi =  | PMID = 15870532 }}</ref>
**Uncommon.
*VIN II.
**Not common.
*VIN III.
**Commonly seen.


===Microscopic===
===Microscopic===
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**May have "vertical streaming" - the long axis of the cells are perpendicular to the free surface & basement membrane.
**May have "vertical streaming" - the long axis of the cells are perpendicular to the free surface & basement membrane.
*Apical mitoses.
*Apical mitoses.
DDx:
*[[Condyloma acuminatum]].


Images:
Images:
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