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Difference between revisions of "Vulva"
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→Classic vulvar intraepithelial neoplasia: rework a bit
(→Differentiated vulvar intraepithelial neoplasia: +mnemonic) |
m (→Classic vulvar intraepithelial neoplasia: rework a bit) |
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==Classic vulvar intraepithelial neoplasia== | ==Classic vulvar intraepithelial neoplasia== | ||
*Abbreviated ''classic VIN''. | |||
* | |||
===General=== | ===General=== | ||
*Classic VIN is | Epidemiology: | ||
*Classic VIN, like CIN, is associated with [[HPV]] and seen in younger women. | |||
Classic VIN is graded like cervical pre-cancerous lesions: | |||
* | *VIN I. | ||
** | **DDx: [[condyloma acuminatum]].<ref name=pmid15870532>{{Cite journal | last1 = Rufforny | first1 = I. | last2 = Wilkinson | first2 = EJ. | last3 = Liu | first3 = C. | last4 = Zhu | first4 = H. | last5 = Buteral | first5 = M. | last6 = Massoll | first6 = NA. | title = Human papillomavirus infection and p16(INK4a) protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma. | journal = J Low Genit Tract Dis | volume = 9 | issue = 2 | pages = 108-13 | month = Apr | year = 2005 | doi = | PMID = 15870532 }}</ref> | ||
**Uncommon. | |||
*VIN II. | |||
**Not common. | |||
*VIN III. | |||
**Commonly seen. | |||
===Microscopic=== | ===Microscopic=== | ||
| Line 51: | Line 49: | ||
**May have "vertical streaming" - the long axis of the cells are perpendicular to the free surface & basement membrane. | **May have "vertical streaming" - the long axis of the cells are perpendicular to the free surface & basement membrane. | ||
*Apical mitoses. | *Apical mitoses. | ||
DDx: | |||
*[[Condyloma acuminatum]]. | |||
Images: | Images: | ||