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Difference between revisions of "Tissue floater"
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A '''tissue floater''', also '''floater''', is a contaminant that is transferred to the slide some time during tissue processing.<ref name=pmid19492892>{{Cite journal | last1 = Platt | first1 = E. | last2 = Sommer | first2 = P. | last3 = McDonald | first3 = L. | last4 = Bennett | first4 = A. | last5 = Hunt | first5 = J. | title = Tissue floaters and contaminants in the histology laboratory. | journal = Arch Pathol Lab Med | volume = 133 | issue = 6 | pages = 973-8 | month = Jun | year = 2009 | doi = 10.1043/1543-2165-133.6.973 | PMID = 19492892 | URL = http://www.archivesofpathology.org/doi/full/10.1043/1543-2165-133.6.973}}</ref> | A '''tissue floater''', also '''floater''', is a contaminant that is transferred to the slide some time during tissue processing.<ref name=pmid19492892>{{Cite journal | last1 = Platt | first1 = E. | last2 = Sommer | first2 = P. | last3 = McDonald | first3 = L. | last4 = Bennett | first4 = A. | last5 = Hunt | first5 = J. | title = Tissue floaters and contaminants in the histology laboratory. | journal = Arch Pathol Lab Med | volume = 133 | issue = 6 | pages = 973-8 | month = Jun | year = 2009 | doi = 10.1043/1543-2165-133.6.973 | PMID = 19492892 | URL = http://www.archivesofpathology.org/doi/full/10.1043/1543-2165-133.6.973}}</ref> | ||
Floaters are considered to be near-misses, as they can lead to misdiagnoses if not identified as such.<ref name=pmid22032570>{{Cite journal | last1 = Smith | first1 = ML. | last2 = Raab | first2 = SS. | title = Assessment of latent factors contributing to error: addressing surgical pathology error wisely. | journal = Arch Pathol Lab Med | volume = 135 | issue = 11 | pages = 1436-40 | month = Nov | year = 2011 | doi = 10.5858/arpa.2011-0334-OA | PMID = 22032570 | URL = http://www.archivesofpathology.org/doi/full/10.5858/arpa.2011-0334-OA}}</ref> | A tissue floater is a type of ''extraneous tissue''; tissue that is foreign to the case.<ref name=pmid22031316>{{Cite journal | last1 = Layfield | first1 = LJ. | last2 = Witt | first2 = BL. | last3 = Metzger | first3 = KG. | last4 = Anderson | first4 = GM. | title = Extraneous tissue: a potential source for diagnostic error in surgical pathology. | journal = Am J Clin Pathol | volume = 136 | issue = 5 | pages = 767-72 | month = Nov | year = 2011 | doi = 10.1309/AJCP4FFSBPHAU8IU | PMID = 22031316 | URL = http://ajcp.ascpjournals.org/content/136/5/767.long }}</ref> | ||
==Quality== | |||
{{Main|Quality}} | |||
Floaters are considered to be near-misses, as they can lead to misdiagnoses if not identified as such.<ref name=pmid22032570>{{Cite journal | last1 = Smith | first1 = ML. | last2 = Raab | first2 = SS. | title = Assessment of latent factors contributing to error: addressing surgical pathology error wisely. | journal = Arch Pathol Lab Med | volume = 135 | issue = 11 | pages = 1436-40 | month = Nov | year = 2011 | doi = 10.5858/arpa.2011-0334-OA | PMID = 22032570 | URL = http://www.archivesofpathology.org/doi/full/10.5858/arpa.2011-0334-OA}}</ref> They are considered to be an indicator of (poor) quality. | |||
==Management== | ==Management== | ||
*Floaters are not found in the tissue block.<ref name=pmid22031316/> | |||
**Contaminants in the tissue block, i.e. paraffin, are known as "pick-up" and generally result conditions at the grossing bench. | |||
*Tissue that cannot be definitely identified as a floater may require identity testing, using short tanden repeat (STR) DNA testing.<ref name=pmid19745614>{{Cite journal | last1 = Mosse | first1 = CA. | last2 = Stumph | first2 = JR. | last3 = Best | first3 = DH. | last4 = Vnencak-Jones | first4 = CL. | title = A B-cell lymphoma diagnosed in floater tissue: implications of the diagnosis and resolution of a laboratory error. | journal = Am J Med Sci | volume = 338 | issue = 3 | pages = 248-51 | month = Sep | year = 2009 | doi = 10.1097/MAJ.0b013e3181a88dc0 | PMID = 19745614 }}</ref> | *Tissue that cannot be definitely identified as a floater may require identity testing, using short tanden repeat (STR) DNA testing.<ref name=pmid19745614>{{Cite journal | last1 = Mosse | first1 = CA. | last2 = Stumph | first2 = JR. | last3 = Best | first3 = DH. | last4 = Vnencak-Jones | first4 = CL. | title = A B-cell lymphoma diagnosed in floater tissue: implications of the diagnosis and resolution of a laboratory error. | journal = Am J Med Sci | volume = 338 | issue = 3 | pages = 248-51 | month = Sep | year = 2009 | doi = 10.1097/MAJ.0b013e3181a88dc0 | PMID = 19745614 }}</ref> | ||