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Difference between revisions of "Medical liver disease"
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→Drug-induced liver disease: rework
(→Drug toxicity: rename) |
(→Drug-induced liver disease: rework) |
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==Drug-induced liver disease== | ==Drug-induced liver disease== | ||
===General=== | |||
*Drugs can do almost anything; may include: [[granulomata]], bile duct loss, cholestasis, ischemic type injury. | *Drugs can do almost anything; may include: [[granulomata]], bile duct loss, cholestasis, ischemic type injury. | ||
*Effects can be delayed -- temporal relationship not always obvious. | *Effects can be delayed -- temporal relationship not always obvious. | ||
Microscopic: | ===Microscopic=== | ||
Features: | |||
*Non-specific findings. | *Non-specific findings. | ||
**+/-Eosinophils<ref>{{Ref DCHH|166}}</ref> - '''significant suggestive finding'''. | **+/-Eosinophils<ref>{{Ref DCHH|166}}</ref> - '''significant suggestive finding'''. | ||
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*[http://commons.wikimedia.org/wiki/File:Drug-induced_hepatitis_intermed_mag.jpg Drug-induced hepatitis - intermed. mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Drug-induced_hepatitis_intermed_mag.jpg Drug-induced hepatitis - intermed. mag. (WC)]. | ||
===Specific patterns=== | ====Specific patterns==== | ||
Acute hepatits: | Acute hepatits: | ||
*Related to Rx - most often antibiotics. | *Related to Rx - most often antibiotics. | ||
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*Carbamazepine - seizures. | *Carbamazepine - seizures. | ||
===Specific drugs=== | ====Specific drugs==== | ||
Acetaminophen: | Acetaminophen: | ||
*Zone 3 necrosis. | *Zone 3 necrosis. | ||