Difference between revisions of "Pancreas"

Pancreas (view source)

525 bytes added , 19:18, 4 May 2012

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 *Abysmal prognosis.
-Molecular characteristics:<ref name=Ref_PCPBoD8_470-1>{{Ref PCPBoD8|470-1}}</ref>
+Risk factors:<ref name=Ref_PCPBoD8_471>{{Ref PCPBoD8|471}}</ref>
-*KRAS (oncogene) mutation in ~ 90% of cases.
+*Smoking (RR ~ 2).
-*CDKN2A<ref name=omim600160>{{OMIM|600160}}</ref> (tumour suppressor) inactivation ~ 95% of cases.
+*Pancreatitis.
-**[[AKA]] p16.
+*Family history, esp. BRCA2.
+*[[Diabetes mellitus]] - modest risk increase.
+Molecular characteristics:<ref name=Ref_PCPBoD8_470-1>{{Ref PCPBoD8|470-1}}</ref><ref name=pmid19896096>{{Cite journal  | last1 = Furukawa | first1 = T. | title = Molecular pathology of pancreatic cancer: implications for molecular targeting therapy. | journal = Clin Gastroenterol Hepatol | volume = 7 | issue = 11 Suppl | pages = S35-9 | month = Nov | year = 2009 | doi = 10.1016/j.cgh.2009.07.035 | PMID = 19896096 }}</ref>
+#KRAS (oncogene) mutation in ~ 90% of cases.
+#CDKN2A<ref name=omim600160>{{OMIM|600160}}</ref> ([[AKA]] p16) inactivation ~ 95% of cases.
+#TP53 (AKA p53).
+#SMAD4.
 ===Microscopic===