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Difference between revisions of "An introduction to head and neck pathology"
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An introduction to head and neck pathology (view source)
Revision as of 00:12, 3 May 2012
, 00:12, 3 May 2012→Olfactory neuroblastoma: add more
(→Olfactory neuroblastoma: add more) |
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*[[AKA]] ''esthesioneuroblastoma''. | *[[AKA]] ''esthesioneuroblastoma''. | ||
===General=== | ===General=== | ||
Epidemiology:<ref name=pmid20596981/> | |||
*Prognosis: poor. | *Prognosis: poor. | ||
*Wide age range with bimodal distribution - teens and 60s. | |||
*No sex predilection. | |||
Clinical presentation:<ref name=pmid20596981>{{Cite journal | last1 = Thompson | first1 = LD. | title = Olfactory neuroblastoma. | journal = Head Neck Pathol | volume = 3 | issue = 3 | pages = 252-9 | month = Sep | year = 2009 | doi = 10.1007/s12105-009-0125-2 | PMID = 20596981 | PMC = 2811627 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811627/?tool=pubmed }}</ref> | |||
*Nasal obstruction ~ 70%. | |||
*Epistaxis ~ 50%. | |||
*Anosmia. | |||
*Headache. | |||
===Gross=== | |||
*Arises from olfactory mucosa - upper nasal cavity.<ref name=Ref_WMSP41>{{Ref WMSP|41}}</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref name=pmid20596981/> | ||
*[[Small round cell tumour|Small round (blue) cell tumour]]. | *[[Small round cell tumour|Small round (blue) cell tumour]] with: | ||
**Stippled chromatin. | |||
**High NC ratio. | |||
*+/-Flexner-Wintersteiner [[rosette]] - | |||
DDx: | DDx: | ||
*Lymphoma. | *[[Lymphoma]]. | ||
*Small cell carcinoma. | *[[Small cell carcinoma]]. | ||
*Other [[small round cell tumours]]. | *Other [[small round cell tumours]]. | ||
*Basaloid squamous carcinoma. | *Basaloid squamous carcinoma.{{fact}} | ||
Images: | |||
*[http://path.upmc.edu/cases/case467/images/fig02.jpg Olfactory neuroblastoma - crappy image (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case467.html http://path.upmc.edu/cases/case467.html]. Accessed on: 21 January 2012.</ref> | *[http://path.upmc.edu/cases/case467/images/fig02.jpg Olfactory neuroblastoma - crappy image (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case467.html http://path.upmc.edu/cases/case467.html]. Accessed on: 21 January 2012.</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811627/figure/Fig6/ Olfactory neuroblastoma (nih.gov)].<ref name=pmid20596981/> | |||
===IHC=== | ===IHC=== | ||
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Others: | Others: | ||
*CD45 -ve (r/o [[lymphoma]]). | *CD45 -ve (r/o [[lymphoma]]). | ||
*AE1/AE3 -ve (r/o carcinoma). | *AE1/AE3 usu. -ve (r/o carcinoma). | ||
*CAM5.2 usu. -ve -- up to 35% +ve.<ref name=Ref_WMSP41>{{Ref WMSP|41}}</ref> | |||
==Craniopharyngioma== | ==Craniopharyngioma== | ||