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Difference between revisions of "Ovarian tumours"
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→Adult granulosa cell tumour: +normal granulosa cells
(→Adult granulosa cell tumour: +normal granulosa cells) |
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| Line 724: | Line 724: | ||
*May secrete estrogen. | *May secrete estrogen. | ||
**May present with endometrial pathology, e.g. [[endometrial hyperplasia]] ''or'' endometrioid [[endometrial carcinoma]]. | **May present with endometrial pathology, e.g. [[endometrial hyperplasia]] ''or'' endometrioid [[endometrial carcinoma]]. | ||
**Occasionally secrete antrogens lead to virilization.<ref name=pmid19062005>{{Cite journal | last1 = Patel | first1 = SS. | last2 = Carrick | first2 = KS. | last3 = Carr | first3 = BR. | title = Virilization persists in a woman with an androgen-secreting granulosa cell tumor. | journal = Fertil Steril | volume = 91 | issue = 3 | pages = 933.e13-5 | month = Mar | year = 2009 | doi = 10.1016/j.fertnstert.2008.10.038 | PMID = 19062005 }}</ref> | |||
Note: | |||
*Normal granulosa cells convert androgen from the theca cells to estrogen and/or progesterone.<ref name=pmid15541573>{{Cite journal | last1 = Havelock | first1 = JC. | last2 = Rainey | first2 = WE. | last3 = Carr | first3 = BR. | title = Ovarian granulosa cell lines. | journal = Mol Cell Endocrinol | volume = 228 | issue = 1-2 | pages = 67-78 | month = Dec | year = 2004 | doi = 10.1016/j.mce.2004.04.018 | PMID = 15541573 }}</ref> | |||
===Gross=== | ===Gross=== | ||